Evadol

• Peri- and postmenopausal estrogen deficiency symptoms: Used for treatment of hot flushes, night sweats and mood changes.
• Osteoporosis prevention: Used for prevention of bone loss and fractures in postmenopausal women.

Estradiol enters target cells freely and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell.

Adult Dose:

• Estrogen-only therapy: 1 mg tablet daily (progestogen should be added if uterus is intact).
• Control of menopausal symptoms: Lowest effective dose for shortest duration should be used.
• Initiation: Start with 1 mg; if necessary, 2 mg should be used.

Common Side Effects:

• Breast cancer (more common with HRT use)
• Endometrial hyperplasia or cancer
• Ovarian cancer
• Venous thromboembolism
• Heart disease
• Stroke
• Breast pain, tenderness or enlargement
• Headache, migraine
• Dizziness
• Nausea
• Abdominal pain
• Muscle cramps
• Fluid retention
• Weight changes

Use in Pregnancy: Not indicated during pregnancy. If pregnancy occurs, treatment should be withdrawn.

Precautions:

• HRT should only be initiated for symptoms that adversely affect quality of life.
• Annual risk-benefit assessment should be undertaken.
• Complete personal and family medical history should be taken before initiation.
• Physical (including pelvic and breast) examination should be done.
• Periodic check-ups recommended during treatment.
• Any changes in breasts should be reported to doctor.

Overdose: Overdose may cause nausea, vomiting and withdrawal bleeding. No specific antidotes; symptomatic treatment.

Storage: Store below 30 degree C in a dry place. Keep away from light. Keep out of reach of children.