Excedrin PM Sleep Aid with Headache Relief Caplets for Nighttime Headaches and Sleeplessness - 100 Count
250mg+250mg+38mgOTC৳ 4,490/unit
Pack: ৳ 4,490
৳ 4,490/unit
Pack: ৳ 4,490
At a glance
Acetaminophen (paracetamol) is an analgesic and antipyretic used for mild to moderate pain and fever. It inhibits prostaglandin synthesis in the central nervous system.
Indications
Fever (antipyretic) and mild to moderate pain (analgesic) such as headache, toothache, muscle pain, menstrual pain, sore throat, and post-immunization fever.
Pharmacology
Acetaminophen is an analgesic and antipyretic. Its exact mechanism is not fully understood, but it inhibits prostaglandin synthesis in the central nervous system and has selective effects on cyclooxygenase (COX) enzymes. It has weak anti-inflammatory action. Oral bioavailability is approximately 80%. Plasma half-life is approximately 2-3 hours.
Dosage
Adults: 650-1000 mg every 4-6 hours; maximum daily dose 4000 mg.
Children (weight-based):
- 2-4 years: 160 mg every 4-6 hours
- 4-6 years: 240 mg every 4-6 hours
- 6-9 years: 320 mg every 4-6 hours
- 9-11 years: 320-400 mg every 4-6 hours
- 11-12 years: 320-480 mg every 4-6 hours
- Children: every 4 hours, no more than 5 doses in 24 hours
Under 2 years: As directed by physician.
Side effects
Common side effects: Rare; generally well tolerated.
Serious side effects:
- Hepatotoxicity (liver necrosis) in overdose
- Severe skin reactions (rare)
- High anion gap metabolic acidosis (in at-risk patients)
Use in pregnancy
Pregnancy Category: B. Can be used safely during pregnancy. Fever and pain treatment is important; avoid chronic or high-dose use.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
Considered safe during pregnancy and lactation. Caution in liver or severe kidney disease. Caution in patients with history of alcohol consumption. Patients with phenylketonuria (PKU) should avoid brands containing aspartame.
Overdose effects
Overdose symptoms: Nausea, vomiting, anorexia, sweating, lethargy.
Toxic dose: Adults: ≥10 g/24 hours; Children: ≥150 mg/kg.
Treatment: N-acetylcysteine (NAC) as soon as possible (most effective within 8 hours). Activated charcoal, symptomatic supportive measures.
Storage conditions
Store in a cool and dry place, protected from light and moisture. Below 30°C. Keep out of reach of children.