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At a glance

Guaiphenesin + Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride is a combination syrup used for upper respiratory tract disorders and productive cough.

Indications
  • Upper respiratory tract disorders
  • Productive cough
  • Allergic rhinitis
  • Sneezing
  • Cough & runny nose
  • Nasal congestion
Pharmacology

Triprolidine hydrochloride is a potent competitive histamine H1-receptor antagonist with antimuscarinic and mild sedative properties. Pseudoephedrine is both an alpha- and beta-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa and directly stimulates beta-adrenergic receptors causing bronchial relaxation and increased heart rate. Guaifenesin increases the volume and reduces the viscosity of tenacious sputum and is used as an expectorant for productive cough.

Dosage

Adults and children over 12 years:

  • 10 ml (2 teaspoonful) three times a day

Children 6-12 years:

  • 5 ml (1 teaspoonful) three times a day

Children 2-5 years:

  • 2.5 ml (1/2 teaspoonful) three times a day

Under 2 years:

  • Physician's advice preferred

* Use as directed by the registered physician

Side effects

Common Side Effects:

  • CNS depression or excitation
  • Sleep disturbance
  • Hallucination (rare)
  • Skin rashes
  • Tachycardia
  • Dryness of mouth, nose and throat
  • Urinary retention (in men)
Use in pregnancy

Use in Pregnancy: Widespread use without apparent ill consequence, but specific data lacking. Use with caution.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings

Precautions:

  • May cause drowsiness - do not drive or operate machinery
  • Avoid alcohol or other centrally acting sedatives
  • Caution in hypertension, heart disease, diabetes, hyperthyroidism, elevated intraocular pressure and prostatic enlargement
  • Do not use for persistent or chronic cough such as smoking, asthma or emphysema
Overdose effects

Overdose: Drowsiness, irritability, restlessness, dizziness, gastrointestinal discomfort, respiratory depression, convulsions, tachycardia and hypertension may occur. Support respiration and control convulsions. Gastric lavage and bladder catheterization may be necessary.

Storage conditions

Storage: Store below 25°C. Protect from light. Do not refrigerate.

Guaiphenesin + Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.