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At a glance

Famotidine is an antacid medicine used to reduce stomach acid and treat heartburn, indigestion, and peptic ulcers.

Indications
  • Gastroesophageal Reflux Disease (Acid Reflux): Used for treatment of acid reflux.
  • Peptic Ulcer Disease: Used for treatment of gastric and duodenal ulcers.
  • Gastric Ulcer: Used for treatment of stomach ulcers.
  • Zollinger-Ellison Syndrome: Used for treatment of excessive acid secretion.
Pharmacology

Famotidine is a histamine H2-receptor antagonist. Famotidine completely inhibits the action of histamine on H2-receptors of parietal cell. It inhibits basal, overnight and pentagastrin stimulated gastric acid secretion.

Dosage

Adult Dose (Oral):

  • Benign Gastric and Duodenal Ulcer: 40 mg daily at bedtime for 4-8 wk or 20 mg bid.
  • Gastroesophageal Reflux Disease: 20 mg bid for 6-12 wk or up to 40 mg bid if esophageal ulceration.
  • Zollinger-Ellison Syndrome: Initially 20 mg 6 hrly, up to 800 mg/day if necessary.
  • Non-ulcer Dyspepsia, Heartburn: 10-20 mg once or bid.

Child Dose (1-16 years): Peptic Ulcer: 0.5 mg/kg PO at bedtime; max 40 mg/day.

Side effects

Common Side Effects:

  • Headache
  • Diarrhea
  • Constipation
  • Nausea
  • Vomiting
  • Skin rash
  • Dizziness
  • Drowsiness
Use in pregnancy

Use in Pregnancy: Famotidine is generally considered safe during pregnancy; animal studies have shown low or no adverse effects.

Pregnancy Category: B — always consult a doctor before taking during pregnancy.

Precautions & warnings

Precautions:

  • Famotidine does not usually affect your ability to drive.
  • Take with or without food.
  • If taking antacids, take them 2 hours before or after Famotidine.
  • Avoid soft drinks, citrus fruits (orange, lemon) which can irritate the stomach and increase acid secretion.
  • Inform doctor if no improvement after 2 weeks.
  • Inform doctor if diagnosed with kidney disease (dose may need adjustment).
  • Do not stop taking without talking to your doctor.
Overdose effects

Overdose: Limited information on overdose; symptomatic treatment.

Storage conditions

Storage: Keep below 30 degree C, away from light and moisture. Keep out of reach of children.

Famotidine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.