৳ 350/unit
Pack: ৳ 7,000
৳ 350/unit
Pack: ৳ 7,000
At a glance
Nintedanib is a tyrosine kinase inhibitor used for Idiopathic Pulmonary Fibrosis (IPF), chronic fibrosing interstitial lung diseases and systemic sclerosis-associated ILD, and with docetaxel in NSCLC.
Indications
- Idiopathic Pulmonary Fibrosis (IPF)
- Chronic fibrosing interstitial lung diseases (progressive phenotype)
- Systemic sclerosis-associated interstitial lung disease (SSc-ILD)
- Locally advanced, metastatic or locally recurrent NSCLC (with docetaxel)
Pharmacology
Nintedanib binds to ATP-binding pocket of multiple RTKs (PDGFR, FGFR, VEGFR, FLT3) and nRTKs (Lck, Lyn, Src) to inhibit their activity. It prevents lung fibroblast proliferation and migration and induces apoptosis of tumor cells.
Dosage
IPF/ILD/SSc-ILD:
- 150 mg twice daily approximately 12 hours apart
- 100 mg twice daily if not tolerated
NSCLC (with Docetaxel):
- 200 mg twice daily on days 2-21 of 21-day cycle
Side effects
Common Side Effects (≥10%):
- Diarrhea (62.4%)
- Nausea
- Vomiting
- Abdominal pain
- Decreased appetite
- Weight decreased
- Hepatic enzyme increased
Serious: Hepatotoxicity, hemorrhage, GI perforation, arterial thromboembolic events
Use in pregnancy
Use in Pregnancy: Nintedanib is highly unsafe during pregnancy; definite evidence of severe fetal harm. Do not use.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Manage diarrhea with hydration and loperamide
- Monitor hepatic enzymes regularly (first 3 months)
- Patients with low body weight (<65 kg), Asian and female have higher risk of liver enzyme elevations
- Risk of bleeding; caution with anticoagulants
- Risk of GI perforation; start 4 weeks after abdominal surgery
- Can cause fetal harm; use effective contraception
Overdose effects
No specific treatment for overdose; symptomatic supportive measures.
Storage conditions
Store in a cool and dry place, protected from light; do not store above 25°C.