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Melatonin is a prescription medicine used in the treatment of insomnia and jet lag (a sleep disorder due to frequent travel to different time zones). It reduces jet lag symptoms such as irritability, indigestion, daytime tiredness, and sleep disturbances. Melatonin helps to synchronize the body's biological day-night rhythm. It should be taken either 2 hours before or 2 hours after food, preferably at bedtime. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. You should never skip any doses and finish the full course of treatment even if you feel better. This medicine should not be stopped suddenly without talking to your doctor. Some common side effects of this medicine include headache and drowsiness. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It is important to note that this medicine should not be used for daily naps. Consult your doctor before taking this medicine if you are suffering from any liver or kidney problems. You should avoid smoking and alcohol while using this medicine. Pregnant and breastfeeding mothers should not use this medicine. However, if the need arises, please consult your doctor before using it. Melatonin is a natural hormone which regulates the sleep-wake cycle and helps you fall asleep.

• Insomnia • Jet lag

Melatonin is the hormone secreted by the pineal gland. In humans, the plasma levels of melatonin are high at night and low during the day and it appears to have a role in circardian rhythm regulation.

Adult Dose: Oral Disturbed biorhythms; Sleep disorders Adult: Usual dose 3-6 mg at bedtime. Child Dose: Oral Disturbed biorhythms; Sleep disorders Child: 2-3 mg at bedtime, increased after 1-2 wk to 4-6 mg if needed. Max dose 10 mg.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Melatonin is to be taken empty stomach.

Common: • Headache • Drowsiness

[UNSAFE] Melatonin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Take it with or without food or at least 2 hours before bedtime. It is the safest medication with no dependence, no side effects, or no drug tolerance. Some lifestyle habits for good sleep: It may affect the blood sugar level. Take caution while taking this medicine if you are suffering from diabetes. It may cause dizziness. Don't drive or do anything requiring concentration until you know how it affects you. Smoking may make Melatonin less effective since it can increase the metabolism (breakdown) of it by the liver. Avoid alcohol while taking this medicine as it may decrease the activity of drug. Inform your doctor if you are taking seizures medicine as Melatonin may increase the frequency of Seizures. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Do not take this medicine if you are allergic to Melatonin, suffering from liver or kidney, or if you have an intolerance to some sugars.

Pregnancy and lactation.

Quinolones; carbamazepine, rifampicin; fluvoxamine, 5- or 8-methoxypsoralen, cimetidine, cigarette smoking, oestrogens. Alcohol; zalepon, zolpidem, zopiclone; thioridazine, imipramine.

[UNSAFE] It is unsafe to consume alcohol with Melatonin.

[CONSULT YOUR DOCTOR] Information regarding the use of Melatonin during pregnancy is not available. Please consult your doctor.

[SAFE IF PRESCRIBED] Melatonin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Melatonin in patients with kidney disease. Please consult your doctor. However, based on the limited information available it is advised that Melatonin should be used with caution in patients with kidney disease. [CAUTION] Melatonin should be used with caution in patients with liver disease. Dose adjustment of Melatonin may be needed. Please consult your doctor. There is very limited experience on use of Melatonin in patients with underlying liver disease.

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