৳ 26.29/unit
Pack: ৳ 26.29
৳ 26.29/unit
Pack: ৳ 26.29
At a glance
Amoxicillin is a penicillin-type antibiotic used to treat a variety of bacterial infections. It is effective in infections of the throat, ear, nasal sinuses, respiratory tract (e.g. pneumonia), urinary tract, skin and soft tissue, and typhoid fever. Amoxicillin is also used to prevent infection of the heart valves (bacterial endocarditis) and to eliminate H. pylori in peptic ulcer disease.
Indications
- Throat, ear & sinus infections
- Respiratory tract infections (including pneumonia)
- Urinary tract infections
- Skin and soft tissue infections
- Typhoid fever
- H. pylori infection (peptic ulcer)
- Bacterial endocarditis prophylaxis
- Dental abscess
- Gonorrhea
Pharmacology
Amoxicillin is a broad-spectrum antibiotic belonging to the penicillin class. It inhibits bacterial cell wall synthesis, leading to bacterial destruction. Amoxicillin binds to penicillin-binding proteins (PBPs) and inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall, resulting in bacterial lysis.
Amoxicillin is effective against both Gram-positive and Gram-negative bacteria. It is acid-stable and rapidly absorbed after oral administration.
Dosage
Adult Dosage:
- Sensitive infections: 250-500 mg every 8 hours
- Severe/recurrent respiratory infections: 3 g twice daily
- Uncomplicated gonorrhea (with probenecid): 3 g as a single dose
- Dental abscess: 3 g, repeated once after 8 hours
- Uncomplicated acute UTI: 3 g, repeated once after 10-12 hours
- Endocarditis prophylaxis: 2 or 3 g as single dose 1 hour before dental procedure
- H. pylori infection: 500 mg 3 times daily with metronidazole/clarithromycin and bismuth or antisecretory drug
- IV/IM (sensitive infections): 500 mg every 8 hours
- Listerial meningitis: 2 g every 4 hours with other antibiotics (10-14 days)
Pediatric Dosage:
- Standard dose: 40-45 mg/kg/day (every 8-12 hours)
- High dose: 80-90 mg/kg/day, max 4 g/day (every 12 hours)
- Penicillin-resistant S. pneumoniae otitis media: 150 mg/kg/day (every 8 hours)
Renal Dose: Dose adjustment may be needed in severe renal impairment.
Side effects
- Rash (with fever)
- Vomiting
- Allergic reactions
- Nausea
- Diarrhea
Use in pregnancy
[SAFE IF PRESCRIBED] Amoxicillin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Use under doctor's supervision.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
Important Precautions:
- Inform your doctor if you are allergic to penicillin or penicillin-type medicines
- Complete the full course - do not stop even if you feel better
- Stop and inform your doctor immediately if you develop allergic reactions (rash, swelling of face/throat/tongue, breathing difficulties)
- Inform your doctor if you notice bloody stools or abdominal cramps
- Caution in infectious mononucleosis
- Caution in renal and hepatic disease
Overdose effects
Overdose may cause nausea, vomiting, diarrhea, and electrolyte imbalance. Consult your doctor if symptoms occur.
Storage conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.