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At a glance

Phenylephrine + Promethazine is a combination syrup used for temporary relief of upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold.

Indications
  • Upper respiratory symptoms including nasal congestion associated with allergy or common cold
Pharmacology

Phenylephrine is an α-adrenergic agonist that constricts nasal mucosal blood vessels to relieve nasal congestion. Promethazine is an H1 receptor antagonist that reduces allergic reactions and provides sedative and antiemetic effects.

Dosage

Adults and ≥12 years: 1 teaspoonful (5 mL) every 4-6 hours; max 6 teaspoonfuls (30 mL)/24 hours

6-12 years: ½-1 teaspoonful (2.5-5 mL) every 4-6 hours; max 6 teaspoonfuls (30 mL)/24 hours

2-6 years: ¼-½ teaspoonful (1.25-2.5 mL) every 4-6 hours

Under 2 years: Not recommended

Side effects

Side Effects:

  • Drowsiness/sedation
  • Dizziness
  • Dry mouth
  • Nausea
  • Vomiting
  • Blurred vision
  • Confusion
  • Extrapyramidal symptoms
  • Increased or decreased blood pressure
  • Rash
  • Photosensitivity
Use in pregnancy

Use in Pregnancy: Pregnancy Category C; use only if clearly needed.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May impair driving ability; do not drive if drowsy or dizzy
  • Alcohol, narcotic analgesics, sedatives, hypnotics, TCAs, tranquilizers: Additive sedative effects
  • Caution in cardiovascular disease, hypertension
  • Caution in liver function impairment
  • May lower seizure threshold
  • Caution in narrow-angle glaucoma, stenosing peptic ulcer, prostatic hypertrophy
Overdose effects

Overdose: From mild CNS and cardiovascular depression to profound hypotension, respiratory depression, unconsciousness, sudden death, hypertension, headache, convulsions, cerebral hemorrhage, and vomiting. Treatment: Activated charcoal; sodium or magnesium sulfate as a cathartic.

Storage conditions

Do not store above 30°C; keep away from light; keep out of reach of children.

Phenylephrine + Promethazine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.