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5-Fluorouracil (5-FU) is used in the treatment of cancers of stomach, colon, rectum, breast, and lungs. It may be used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy. 5-Fluorouracil (5-FU) is given as injection under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include increased risk of infection, mouth ulcer, vomiting, weakness, and nausea. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. 5-Fluorouracil (5-FU) is an anticancer medication. It works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This slows the growth of cancer cells and eventually kills them.

• Cancer

Fluorouracil interferes with DNA synthesis by blocking the conversion of deoxyuridylic acid to thymidylic acid. It also interferes with RNA synthesis. This results in an unbalanced growth of the cells. Fluorouracil exerts greater effect on rapidly growing cells as they take up the drug at a faster rate.

Adult Dose: Adult: IV Palliation of malignant neoplasms 12 mg/kg/day (max: 0.8-1g/day) for 3-4 days, if no toxicity occurs, may be followed after 1 day w/ 6 mg/kg on alternate days for another 3-4 doses. May repeat course 4-6 wk later or maintenance doses of 5-15 mg/kg (max: 1 g) may be given wkly. Cancers of Colon, Breast, Ovary, Liver, Pancreas, Rectum, Stomach Various protocols exist 500 mg/sq.meter IV on Days 1-5, OR 450-600 mg/sq.meter IV weekly, OR 200-400 mg/sq.meter IV continuous infusion qD Not to exceed 800 mg/day As an infusion: 15 mg/kg/day (max: 1 g/day), continue until toxicity occurs or a total of 12-15 g is given. May repeat course 4-6 wk later. Intra-arterial Palliation of malignant neoplasms 5-7.5 mg/kg/day as continuous infusion (regional perfusion). Hepatic impairment: Dose reduction may be required. Child Dose: Child: Safety & efficacy not established. Renal Dose: Renal impairment: Dose reduction may be required.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Increased risk of infection • Mouth ulcer • Vomiting • Weakness • Nausea • Loss of appetite • Hair loss • Blisters on fingers/feet • Decreased blood cells (red cells, white cells, and platelets) • Diarrhea

[UNSAFE] 5-Fluorouracil (5-FU) may cause side effects which could affect your ability to drive. 5-Fluorouracil (5-FU) can cause side effects such as nausea and can also produce adverse events on your nervous system which cause visual changes.This may affect your ability to drive. 5-Fluorouracil (5-FU) helps treat cancers of stomach, colon, rectum, breast, and lungs. It is given as an injection into a vein, or as a drip (infusion) into a vein or artery. The dose and the number of treatment cycles needed will depend on the type and stage of cancer that is being treated. It may cause dizziness and visual changes. Do not drive or do anything requiring concentration until you know how it affects you. Your doctor may regularly monitor your blood cells and liver function during treatment with this medicine.

Topical application on mucous membranes, exposure to sunlight, hypersensitivity. Depressed bone marrow function, poor nutritional status, potentially serious infections. Pregnancy and lactation.

May increase warfarin effects. May reduce response to vaccines; possibility of generalized infection with live vaccines. Action may be modified by allopurinol. Leucovorin calcium may enhance the toxicity of fluorouracil.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with 5-Fluorouracil (5-FU). Please consult your doctor.

[CONSULT YOUR DOCTOR] 5-Fluorouracil (5-FU) is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] 5-Fluorouracil (5-FU) is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[SAFE IF PRESCRIBED] 5-Fluorouracil (5-FU) is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of 5-Fluorouracil (5-FU) may not be needed in these patients. Please consult your doctor. [CAUTION] 5-Fluorouracil (5-FU) should be used with caution in patients with liver disease. Dose adjustment of 5-Fluorouracil (5-FU) may be needed. Please consult your doctor.

I am having pain in the throat from yesterday while gulping in. azithromycin 500 mg once daily for 5 daysBetadine Mouth wash 10ml once daily in night for 5 days I can't tolerate. sir when I sleep dry cough heavy star please help. what medicin I take I can't tolerate. .sir when I go to sleep dry cough start I can't sleep. .what medicin I take sir please help sir Use Betadine gargle Mouth wash for gargle in night for 5 night ( 10ml)azithromycin 500 mg once daily for 3 day in morningsyrup Grilinctus BM 5ml 3 times for 3 -5 days Plzz help doctor I suffering fever and cough plzz advice a medicine Azithromycin 500 mg once daily for 3 daysCalpol 650 mg two times daily for 3 daysSyrup Grilinctus 10ml two times daily for 5 day I have cough and cold since last one week I am taking the medicine called Sinarest as suggested by doctor but still the is so much of cough I have 11 months daughter to feed she is also having cough and cold what to do. Y so many days it is taking take syrup trump d 10ml 3 times for 5 days Throat infected It's fesling husky and dry Hi are you there? use Betadine Gargle mouth wash 10ml in night for gargle for 5 nightssyrup Grlinctus BM 5ml 3 times for 5 days I am having recurring tongue and throat ulcers for the last 5 months. I have consulted with ENT Specialist. But presently noticed my right side tonsil is enlarged. Is it cancer? It may be a cancer or infection first go to a cancer surgeon Feeling headache & throth infe calpol 500 mg twice daily for 5 dayslevofloxacin 500 mg twice daily for 5 days feeling fever like due to tonsils Levofloxacin 500 mg twice daily for 5 daysDOLO 500 mg twice daily for 5 days