৳ 800/unit
Pack: ৳ 800
৳ 800/unit
Pack: ৳ 800
At a glance
Fondaparinux is an anticoagulant used for the treatment of deep vein thrombosis and pulmonary embolism.
Indications
- Prophylaxis of deep vein thrombosis (DVT): in patients undergoing hip fracture surgery, hip replacement surgery, knee replacement surgery or abdominal surgery.
- Treatment of DVT or acute pulmonary embolism (PE): when administered in conjunction with warfarin.
Pharmacology
The antithrombotic activity of Fondaparinux is the result of selective inhibition of Factor Xa. By selectively binding to antithrombin III (ATIII), Fondaparinux potentiates (about 300 times) the innate neutralization of Factor Xa by ATIII. Neutralization of Factor Xa interrupts the blood coagulation cascade and thus inhibits thrombin formation and thrombus development. Fondaparinux does not inactivate thrombin and has no known effect on platelet function.
Dosage
Adult Dose (DVT/Pulmonary Embolism Treatment):
- <50 kg: 5 mg SC once daily
- 50-100 kg: 7.5 mg SC once daily
- >100 kg: 10 mg SC once daily
- Administer for 5-9 days (up to 26 days in clinical trials)
Prophylaxis:
- >50 kg: 2.5 mg SC once daily for 5-9 days or up to 10 days
- Hip replacement: 11 days recommended
- Knee or hip fracture: minimum 10-14 days recommended
Renal Impairment (CrCl):
- <20: Contraindicated
- 20-50: 1.5 mg once daily
Children: Safety and efficacy not established.
* Use as directed by the registered physician
Side effects
Common Side Effects:
- Bleeding
- Anemia
- Injection site bleeding, rash and pruritus
- Insomnia
- Hypokalemia
- Dizziness
- Hypotension
- Confusion
- Hematoma
- Post-operative hemorrhage
Use in pregnancy
Use in Pregnancy: Generally considered safe during pregnancy. Animal studies have shown low or no adverse effects to the developing baby.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Increases risk of bleeding - be careful while shaving, cutting nails or using sharp objects.
- Bleeding risk is increased in renal impairment.
- Increased risk in patients with low body weight <50 kg.
- Thrombocytopenia can occur - regular platelet count monitoring recommended.
- Do not discontinue use without consulting your doctor.
Overdose effects
Overdose: Overdose increases the risk of bleeding. No specific antidote. Give supportive care.
Storage conditions
Storage: Store below 25°C. Do not freeze. Keep out of reach of children.