৳ 3.70/unit
Pack: ৳ 3.70
৳ 3.70/unit
Pack: ৳ 3.70
At a glance
Diazepam is a benzodiazepine used for short-term anxiety, alcohol withdrawal, muscle spasm, and epilepsy.
Indications
- Short-term anxiety and agitation
- Alcohol withdrawal
- Muscle spasm
- Epilepsy (status epilepticus, febrile convulsions)
- Premedication for surgical procedures
- Insomnia of hospitalized patients
Pharmacology
Diazepam attaches to the specific site on the GABA receptor and potentiates the effect of GABA, which acts by opening chloride ion channels into cells. This results in hyperpolarization and stabilization of the neuronal membrane.
Dosage
Adult (Anxiety): 2-10 mg PO q6-12hr OR 2-10 mg IV/IM q6-12hr; no more than 30 mg/8 hours.
Adult (Alcohol Withdrawal): 10 mg PO q6-8hr during first 24hr; then 5 mg PO q6-8hr PRN.
Adult (Muscle Spasm): 2-10 mg PO q6-8hr PRN.
Child (Status Epilepticus): 0.2-0.5 mg/kg PR/IV.
Elderly: Half the adult dose.
Side effects
Common: Fatigue, impaired coordination, drowsiness, muscle weakness, dizziness, confusion, tremor, double vision, insomnia, dry mouth, headache.
Higher doses: Somnolence, dizziness, lightheadedness, confusion, ataxia.
Use in pregnancy
Pregnancy Category D. Diazepam is unsafe during pregnancy. There is definite evidence of risk to the developing baby.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
May affect driving ability (drowsiness, forgetfulness, poor coordination). Do not use for more than 4 weeks (high habit-forming potential). Do not stop abruptly (withdrawal symptoms may occur). Caution in myasthenia gravis, respiratory depression, liver disease, kidney disease.
Overdose effects
Overdose may cause sedation, muscle weakness, profound sleep, ataxia, hypotonia, hypotension, respiratory depression, coma and death.
Storage conditions
Store in a cool (below 25°C) and dry place protected from light.