G Hydrocortisone100mg/2ml

• Primary or secondary adrenocortical insufficiency
• Acute adrenocortical insufficiency
• Shock unresponsive to conventional therapy
• Congenital adrenal hyperplasia
• Hypercalcemia associated with cancer
• Nonsuppurative thyroiditis
• Rheumatic Disorders
• Dermatologic Diseases (Allergic States, Severe seborrheic dermatitis, Severe psoriasis, Pemphigus, Severe erythema multiforme)
• Severe allergic conditions (Bronchial asthma, Contact dermatitis, Atopic dermatitis, Serum sickness, Allergic rhinitis, Drug hypersensitivity, Urticarial transfusion reactions, Acute noninfectious laryngeal edema)
• Ophthalmic Diseases (Herpes zoster ophthalmicus, Iritis, Iridocyclitis, Chorioretinitis, Diffuse posterior uveitis, Optic neuritis)
• Gastrointestinal Diseases
• Hematologic Disorders (Autoimmune hemolytic anemia, Idiopathic thrombocytopenic purpura, Secondary thrombocytopenia, Erythroblastopenia)
• Neoplastic Diseases (Leukemias and lymphomas, Acute leukemia of childhood)
• Edematous States
• Acute exacerbations of multiple sclerosis

Adult Dose (Oral):

• Initial dosage: 20-240 mg daily depending on disease
• Replacement therapy in adrenocortical insufficiency: 20-30 mg daily in 2 divided doses

Adult Dose (Injection):

• Acute adrenocortical insufficiency: 100-500 mg 3-4 times/24 hr
• Supplement during anesthesia: 25-50 mg at induction
• Status Asthmaticus: 1-2 mg/kg IV q6hr for 24 hr; maintenance: 0.5-1 mg/kg q6hr
• Intra-articular: 5-50 mg depending on joint size

Child Dose (Injection):

• Acute adrenocortical insufficiency: <1 yr: 25 mg; 1-5 yr: 50 mg; 6-12 yr: 100 mg
• Status Asthmaticus: 1-2 mg/kg IV q6hr for 24 hr; not to exceed 250 mg IV; maintenance: 2 mg/kg/day IV divided q6hr

Common Side Effects:

• Ankle swelling
• Dizziness
• Headache
• Weakness

With prolonged high doses:

• Cardiac arrhythmia
• Esophageal candidiasis
• Menstrual irregularity
• Decreased carbohydrate & glucose tolerance
• Fluid retention
• Weight gain
• Euphoria, mood swings, depression, insomnia, acne

Precautions:

• Caution in history of peptic ulceration (increases incidence of peptic ulceration)
• Caution in congestive heart failure, hypertension, glaucoma, diabetes mellitus and epilepsy
• Tell doctor if you have signs of infection (fever or sore throat)
• Do not stop suddenly without talking to your doctor (may worsen symptoms)
• Withdraw gradually after long-term therapy