G Pethidine100mg/2ml

Pethidine Hydrochloride is a pain relieving medicine. It is used to manage persistent, moderate to severe chronic pain that requires continuous, around-the-clock treatment for an extended period of time. Pethidine Hydrochloride is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), headache, drowsiness, fatigue, vomiting, constipation, dry mouth, and sweating. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. Before using it, you should let your doctor know if you have problems with your heart, liver, or kidneys. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, it is important to ask the advice of your doctor before taking this medicine. Your doctor may also regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment. Pethidine Hydrochloride is an opioid analgesic (pain reliever) which works by blocking transmission of pain signals to the brain to lower pain perception.

• Moderate to severe pain

Pethidine is a phenylpiperidine derivative opioid analgesic. It acts mainly as mu-receptor agonist. Like most, opioid analgesics, it mimics endogenous opioids by activating opioid receptors in the central and peripheral nervous system. It reduces the release of neurotransmitter substances and also reduces the activity of postsynaptic neurons in the spinal cord thus preventing transmission of pain impulse.

Adult Dose: Parenteral Moderate to severe acute pain Adult: 25-100 mg IM/SC inj or 25-50 mg by slow IV inj repeated after 4 hr. Obstetric analgesia Adult: 50-100 mg by IM/SC inj as soon as contractions occur at regular intervals; repeat after 1-3 hr if needed. Max: 400 mg in 24 hr. As a preoperative medication Adult: 25-100 mg IM/SC given 1 hr before surgery. Postoperative pain Adult: 25-100 mg IM/SC inj every 2-3 hr if necessary. Intravenous Adjunct to anaesthesia Adult: 10-25 mg by slow IV inj. Hepatic impairment: Dose reductions may be necessary. Child Dose: Parenteral Moderate to severe acute pain Child: SC/IM: 2 mth to 12 yr: 0.5-2 mg/kg; 12-18 yr: 20-100 mg. Repeat dose every 4-6 hr if needed. IV inj: Neonates and children >12 yr: 0.5-1 mg/kg IV inj every 10-12 hr if needed in those up to 2 mth and every 4-6 hr if needed in older children. 12-18 yr: 25-50 mg every 4-6 hr if needed. Alternatively, >1 mth: Loading dose: 1 mg/kg by IV inj followed by 100-400 mcg/kg/hr via continuous IV infusion adjusted according to response. As a preoperative medication Child: 1-2 mg/kg given IM 1 hr before surgery. Postoperative pain Child: 0.5-2 mg/kg IM every 2-3 hr if necessary. Renal Dose: Renal impairment: Dose reductions may be necessary.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Pethidine Hydrochloride, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Sleepiness • Vomiting • Headache • Dizziness • Nausea • Constipation

[UNSAFE] Pethidine Hydrochloride may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Use Pethidine Hydrochloride as instructed by your doctor. Never take in greater amounts or more often than prescribed. It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery. Avoid consuming alcohol when taking the Pethidine Hydrochloride, as it may cause excessive sleepiness or drowsiness. Inform your doctor if you have ever been diagnosed with kidney or liver problems. Store opioid pain relievers in a safe place and out of reach of others.

Hypersensitivity.

Increased pethidine metabolite levels with aciclovir, cimetidine, ritonavir. Reduced analgesic effects with phenytoin, barbiturates. Additive sedative and/or respiratory depressive effects with alcohol, barbiturates, benzodiazepines, phenothiazines, TCAs, other CNS depressants. Potentially Fatal: Increased risk of serotonin syndrome with MAOIs (not be given concurrently or within 14 days of their discontinuation), serotonin agonists, serotonin reuptake inhibitors, sibutramine, TCAs.

[CAUTION] Caution is advised when consuming alcohol with Pethidine Hydrochloride. Please consult your doctor.

[CONSULT YOUR DOCTOR] Pethidine Hydrochloride may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Pethidine Hydrochloride is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Pethidine Hydrochloride should be used with caution in patients with kidney disease. Dose adjustment of Pethidine Hydrochloride may be needed. Please consult your doctor. [CAUTION] Pethidine Hydrochloride should be used with caution in patients with liver disease. Dose adjustment of Pethidine Hydrochloride may be needed. Please consult your doctor.

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