Gemcitabine PhaRes200mg/vial

Gemcitabine is used in the treatment of non-small cell lung cancer, breast cancer, pancreatic cancer, urinary bladder cancer, and ovarian cancer. Gemcitabine is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, vomiting, loss of appetite, hair loss and low blood platelets. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Gemcitabine interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents the cancer cells from growing and multiplying.

• Non-small cell lung cancer • Breast cancer • Pancreatic cancer • Urinary bladder cancer • Ovarian cancer

Gemcitabine is a synthetic pyrimidine nucleoside and cytarabine analogue which is metabolised intracellularly to active diphosphate and triphosphate nucleosides. It inhibits DNA synthesis by inhibiting DNA polymerase and ribonucleotide reductase. It also induces apoptosis and is primarily active against cells in the S-phase, but may also arrest cells at the G1-S border.

Adult Dose: Pancreatic Cancer Indicated as first-line treatment for locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas 1000 mg/m² IV infusion over 30 minutes once/week x7 weeks; rest 1 week, THEN 1000 mg/m² IV on Days 1, 8, and 15 of each 28-day cycle Various regimens exist including monotherapy and in combination with other chemotherapy agents (eg, erlotinib, paclitaxel protein bound, capecitabine) Non-small Cell Lung Cancer 1000 mg/m² IV infusion over 30 minutes on days 1, 8, and 15 of each 28-day cycle, OR 1250 mg/m² IV infusion over 30 minutes on days 1 and 8 of each 21-day cycle Administer cisplatin 100 mg/m² IV after gemcitabine on day 1 Breast Cancer 1250 mg/m² IV infusion over 30 minutes on Days 1 and 8 of each 21-day cycle With paclitaxel 175 mg/m² on Day 1 as a 3 hr infusion before gemcitabine Ovarian Cancer 1000 mg/m² IV infusion over 30 minutes on Days 1 and 8 of each 21-day cycle With carboplatin AUC 4 on Day 1 after gemcitabine

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Nausea • Vomiting • Loss of appetite • Hair loss • Low blood platelets • Allergic reaction • Breathlessness • Decreased white blood cell count • Increased liver enzymes • Anemia (low number of red blood cells) • Flu-like symptoms • Blood in urine • Skin rash • Protein in urine

[UNSAFE] Gemcitabine may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine. Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.

Concurrent radical radiotherapy; pregnancy, lactation; hypersensitivity.

May increase the anticoagulant effect of warfarin when used together.

[UNSAFE] Gemcitabine may cause excessive drowsiness with alcohol.

[CONSULT YOUR DOCTOR] Gemcitabine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Gemcitabine is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Gemcitabine in patients with kidney disease. Please consult your doctor. Kidney function tests are advised before taking this medicine and regular monitoring is also recommended after the treatment. [CONSULT YOUR DOCTOR] There is limited information available on the use of Gemcitabine in patients with liver disease. Please consult your doctor.

I want to know the symptoms of cancer as I am a smoker Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time. If any symtom of brest cancer if have whats the cure First is confirmation of breast cancerChance of cure depends on stage of cancer What is the purpose of Chemotherepy given at the time of radiotherapy in ca lung small cell carcinoma This is given to enhance the therapeutic effect of radiation therapy which is curative for small cell lung cancer. BREAST CANCER , PET REPORT SAYS INFECTION IN SKELETON. Metastatic breast cancer, send me previous treatment details I am PATIENT have pain in my breastes and feel very weight before one week of my menstrual perieds date Is it any symptoms of breast cancer ? Need your advice And also having back pain during menstrual dates please give your valubel advice No it's not a symptom of breast cancer. I seem to have lung cancer , becoz all the symptoms are same as lung cancer. I test my blood, they suggests me that it is highly probable to lung cancer. Sir what can i do now. This is in preliminary stage Do you think that lung cancer is diagnosed from blood She has breast cancer at 4 sta Dear PATIENT 4 Breast Cancer means that the cancer has spread to other parts of the body. The management of such cancers depends on the site where the cancer has spread and on the receptor status of the breast cancer. If you can share the details with me, I will be happy to let you know the potential management