Gevril

• Schizophrenia and other psychoses (especially paranoid)
• Mania and hypomania
• Anxiety, psychomotor agitation, excitement, violent or dangerously impulsive behavior
• Intractable hiccup
• Nausea and vomiting of terminal illness
• Childhood schizophrenia and autism

Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors - on dopaminergic-receptors (subtypes D1, D2, D3 and D4), on serotonergic-receptors (5-HT1 and 5-HT2), on histaminergic-receptors (H1-receptors), alpha1/alpha2-receptors and on muscarinic (cholinergic) M1/M2-receptors. Additionally, Chlorpromazine is a weak presynaptic inhibitor of Dopamine reuptake.

Adult Dose (Schizophrenia, Psychosis - Oral): Initial: 30-75 mg/day divided q6-12hr; Maintenance: usually 200 mg/day (up to 800 mg/day in some patients; some may require 1-2 g/day).

Adult Dose (Parenteral): 25 mg initially, then 25-50 mg after 1-4 hours, then up to 400 mg q4-6hr until controlled; usual 300-800 mg/day.

Nausea & Vomiting: Oral: 10-25 mg q4-6hr; Parenteral: 25-50 mg q4-6hr.

Preoperative Apprehension: 25-50 mg PO (2-3 hours before) or 12.5-25 mg IM (1-2 hours before).

Intractable Hiccups: 25-50 mg PO q6-8hr; if persists after 2-3 days, 25-50 mg IM q3-4hr; if persists, slow IV infusion.

Pediatric Dose (>6 months): Behavioral disorders: 50-100 mg/day; Nausea: 0.5-1 mg/kg q6-8hr; Preoperative: 0.55 mg/kg 1-2 hours before surgery. <6 months: Safety and efficacy not established.

Elderly: Initial: 1/3-½ of normal adult dose.

Common Side Effects:

• Sleepiness
• Orthostatic hypotension
• Dry mouth
• Abnormality of voluntary movements
• Weight gain
• Increased prolactin level
• Urinary retention
• Constipation
• Muscle stiffness

Rare Side Effects: Nasal congestion, blurred vision, nausea, libido changes, gynecomastia, skin/corneal pigmentation, photosensitivity, blood dyscrasias, leukopenia, eosinophilia, ECG changes, cholestatic jaundice, QT prolongation, lowered seizure threshold.

[CONSULT YOUR DOCTOR] Chlorpromazine Hydrochloride may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. Pregnancy Category C.

• [UNSAFE] Chlorpromazine Hydrochloride may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
• Take it at night to avoid sleepiness during the day.
• Do not stop suddenly without talking to your doctor.
• Do not drink alcohol as it can cause serious breathing problems.
• Inform your doctor if you notice involuntary muscle movements.
• Monitor your weight during treatment.
• Rise slowly if you have been sitting or lying down.

Overdose symptoms: Severe extrapyramidal reactions, hypotension, sedation, coma, seizures, ECG changes. Treatment is symptomatic and supportive.

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.