৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Glibenclamide is an antidiabetic medicine used to control blood sugar in type 2 diabetes mellitus.
Indications
- Type 2 diabetes mellitus
Pharmacology
Glibenclamide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which Glibenclamide lowers blood glucose during long-term administration has not been clearly established. With chronic administration of Glibenclamide in Type 2 diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug.
Dosage
Adult Dose:
- Initial: 2.5-5 mg daily (with breakfast or first main meal)
- Increase by 2.5 mg at weekly intervals
- Maintenance: 1.25-20 mg daily (single or divided doses)
- Maximum: 20 mg daily
- Doses >10 mg daily should be given in 2 divided doses
Elderly: Initial 1.25 mg daily
Children: Safety and efficacy not established
Severe Hepatic/Renal: Contraindicated
* Use as directed by the registered physician
Side effects
Common Side Effects:
- Hypoglycemia (low blood sugar)
- Nausea
- Headache
- Dizziness
Use in pregnancy
Use in Pregnancy: Generally considered safe during pregnancy. Animal studies have shown low or no adverse effects.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Driving ability may be affected if blood sugar is too low or too high.
- Avoid skipping meals.
- Avoid alcohol (increases hypoglycemia risk).
- Regular liver function tests recommended.
- Inform doctor if abdominal pain, loss of appetite, or yellowing of eyes/skin occurs.
Overdose effects
Overdose: Severe hypoglycemic reactions with coma, seizure occur infrequently. Treatment of hypoglycemia: oral glucose or IV dextrose.
Storage conditions
Storage: Store below 30°C, protected from light and moisture. Keep out of reach of children.