৳ 4/unit
Pack: ৳ 40
৳ 4/unit
Pack: ৳ 40
At a glance
Repaglinide is a meglitinide analog used as an adjunct to diet and exercise to lower blood glucose in patients with type 2 diabetes mellitus. It stimulates insulin release from pancreatic beta-cells with rapid onset and rapid elimination.
Indications
- Type 2 diabetes mellitus (not controlled by diet and exercise alone)
- In combination with metformin (when not controlled by either agent alone)
Pharmacology
Repaglinide closes ATP-dependent K+ channels on pancreatic beta-cells, causing depolarization, increased Ca²⁺ influx, and insulin secretion. It has rapid onset and rapid elimination, helping control glucose spikes associated with meals.
Dosage
Adult Dose (Oral):
- No prior treatment or HbA1c <8%: 0.5 mg before each meal
- Prior treatment or HbA1c >8%: 1-2 mg before each meal
- Take immediately or up to 30 minutes before each meal
- Adjust dose at 1-2 week intervals; single dose max 4 mg; max 16 mg/day
- Hepatic impairment: May require longer intervals between adjustments
- Renal impairment (CrCl 20-40): 0.5 mg with meals; titrate slowly
Side effects
Common Side Effects:
- Hypoglycemia (low blood sugar)
- Upper respiratory tract infection
- Diarrhea
- Constipation
- Nausea
- Vomiting
- Joint pain
- Dizziness
- Back pain
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; use only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability (hypoglycemia or hyperglycemia)
- Risk of hypoglycemia: delayed/missed meals, alcohol, other antidiabetic medications
- Carry sugar or fruit juice
- Caution in liver and kidney disease
Overdose effects
Overdose (up to 80 mg): Few adverse effects other than lowering of blood glucose; hypoglycemia did not occur when meals were given; severe hypoglycemic reactions (coma, seizure) are infrequent; treatment: glucose administration, symptomatic supportive care.
Storage conditions
Do not store above 30°C; keep away from light; keep out of reach of children.