৳ 920/unit
Pack: ৳ 920
৳ 920/unit
Pack: ৳ 920
At a glance
Human Menopausal Gonadotrophin is used for ovulation induction in women and spermatogenesis stimulation in men.
Indications
- Female infertility: hypo- or normogonadotropic ovarian insufficiency - stimulation of follicle growth
- Male infertility: hypo- or normogonadotropic hypogonadism - in combination with HCG to stimulate spermatogenesis
- In vitro fertilisation (IVF) procedures and other assisted conception techniques
Pharmacology
Human Menopausal Gonadotrophin directly affects the ovaries and the testes. It has gametotropic and steroidogenic effect. In the ovaries, the FSH-component induces an increase in the number of growing follicles and stimulates their development. FSH increases the production of estradiol in the granulose cells by aromatizing androgens that originate in the Theca cells under the influence of the LH-component. In the testes, FSH induces the transformation of premature to mature Sertoli cells and causes the maturation of the seminal canals and development of the spermatozoa.
Dosage
Female Dose (IM/SC):
- Ovulation induction: 75-150 IU FSH daily, adjust gradually until adequate response
- After pre-ovulatory estradiol level achieved, HCG 5,000-10,000 IU (1-2 days after last HMG dose)
- Start within first 7 days of menstrual cycle
Male Dose (IM/SC):
- First treat with HCG 2 X 5,000 IU/week (until testosterone normalizes)
- Then HMG 75-150 IU FSH 2-3 times weekly (for several months)
IVF/Assisted Conception:
- 75-300 IU FSH daily (start on day 2 or 3 of cycle)
* Use as directed by the registered physician
Side effects
Common Side Effects:
- Ovarian hyperstimulation
- Risk of multiple pregnancy and miscarriage
- Hypersensitivity and local reactions at injection site
- Nausea
- Vomiting
- Joint pain
- Fever
- In men: gynecomastia, acne, weight gain
Serious (Potentially Fatal): Rupture of ovarian cysts and intraperitoneal haemorrhage
Use in pregnancy
Use in Pregnancy: No indication for use during pregnancy.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Hyperprolactinemia or tumors of the pituitary or hypothalamus
- Ovarian enlargement at risk of rupture
- Risk of multiple births
- Regular ultrasound and estradiol monitoring required during treatment
- If unintentional hyperstimulation occurs, discontinue treatment
Overdose effects
Overdose: May lead to ovarian hyperstimulation. Mild hyperstimulation: observation. Severe cases: hospitalization and supportive treatment required.
Storage conditions
Storage: Store at 2°C-8°C. Do not freeze. Can be stored below 25°C for maximum 3 months. Protect from light.