৳ 18.57/unit
Pack: ৳ 18.57
৳ 18.57/unit
Pack: ৳ 18.57
At a glance
Griseofulvin is an antifungal medicine used for fungal infections of skin, nails, scalp and hair.
Indications
- Tinea corporis - 2-4 weeks
- Tinea pedis - 4-8 weeks
- Tinea cruris
- Tinea capitis - 4-6 weeks
- Tinea barbae
- Onychomycosis - fingernails: at least 4 months, toenails: at least 6 months
Pharmacology
Griseofulvin is an orally active antibiotic derived from a species of Penicillium which is used to treat tinea infections. Griseofulvin has a fungistatic effect by its ability to disrupt the mitotic spindle structure of the fungal cell which arrests metaphase in cell division. After oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Dosage
Adult Dose (Ultramicrosize):
- Tinea capitis: 375 mg daily (4-6 weeks)
- Tinea corporis: 375 mg daily (2-4 weeks)
- Tinea pedis: 375 mg daily (4-8 weeks)
- Fingernails: 750 mg daily in divided doses for at least 4 months
- Toenails: 750 mg daily in divided doses for at least 6 months
Child Dose (Ultramicrosize):
- 16-27 kg: 125-187.5 mg daily
- Over 27 kg: 187.5-375 mg daily
- Under 2 years: Dosage not established
* Use as directed by the registered physician
Side effects
Common Side Effects:
- Headache
- Skin rash
- Nausea
- Vomiting
- Diarrhea
- Dizziness
- Fatigue
- Insomnia
- Mental confusion
- Oral thrush
- Epigastric distress
Rare: Proteinuria, leukopenia
Use in pregnancy
Use in Pregnancy: Highly unsafe during pregnancy. Studies have shown significant harmful effects to the developing baby.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Periodic monitoring of organ system function (renal, hepatic, hematopoietic) required for prolonged therapy
- Possibility of cross sensitivity with penicillin
- Photosensitivity reaction may occur - avoid intense natural or artificial sunlight
- Lupus erythematosus or lupus-like syndromes reported
- Not recommended in severe liver disease
Overdose effects
Overdose: Overdose may cause nausea, vomiting, diarrhea, headache. Gastric lavage and supportive care should be given.
Storage conditions
Storage: Store below 25°C in a dry place, protected from light. Keep out of reach of children.