Halotaz

• Plaque psoriasis - in adults

Corticosteroids play a role in cellular signaling, immune function, inflammation and protein regulation. Tazarotene is a retinoid prodrug which is converted to its active form, tazarotenic acid, the carboxylic acid of tazarotene, by deesterification. Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family: RARα, RARβ and RARγ, but shows relative selectivity for RARβ and RARγ and may modify gene expression.

Adult Dose:

• Apply a thin layer once daily to affected areas
• Rub in gently
• Skin should be dry before application after bathing
• Do not exceed approximately 50 g per week

Children and adolescents (under 18 years):

• Safety and effectiveness not evaluated

* Use as directed by the registered physician

Common Side Effects:

• Redness
• Itching
• Swelling
• Burning
• Stinging
• Folliculitis
• Atrophy
• Peeling
• Rash

Rare: Skin ulcer, increased eye pressure, increased sensitivity to sun, skin discoloration

Use in Pregnancy: Contraindicated in pregnancy. Tazarotene is a teratogenic substance.

Precautions:

• Contraindicated in pregnancy - Tazarotene is a teratogenic substance
• In females of reproductive potential, obtain negative pregnancy test within 2 weeks prior to initiating treatment
• Use effective contraception during treatment
• HPA axis suppression may occur - caution with prolonged use or large areas
• Avoid exposure to sunlight and sunlamps
• Do not use on eczematous skin
• If visual symptoms occur, refer to ophthalmologist

Overdose: Excessive prolonged use may suppress HPA axis - reduce or stop use. Appropriate symptomatic treatment should be given.

Storage: Store below 30°C, protected from light. Keep out of reach of children.