Hepamilk140mg

Silymarin [Milk thistle] is a flavonoid derived from Silybum marianum, a plant commonly known as milk thistle. Silymarin [Milk thistle] exhibits hepatoprotective and regenerative properties and is one of the most widely used natural compounds for the treatment of hepatic diseases worldwide, due to its antioxidant, anti-inflammatory, and antifibrotic activities. Silymarin [Milk thistle] also increases hepatic levels of glutathione by raising cysteine availability, while inhibiting its catabolism to taurine that may enhance the antioxidant defense in liver. Silymarin [Milk thistle] was found to oppose oxidative stress, and to slow the progression of hepatic fibrosis in alcohol-fed baboons. Different mechanisms of action of Silymarin [Milk thistle] are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as Silymarin [Milk thistle] has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of Silymarin [Milk thistle] is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp), organic anion uptake transporter peptides (OATP), bile salt export pump, and TNF-α-dependent transporters.

Silymarin [Milk thistle] is used for the treatment of Jaundice,chronic inflammatory liver conditions, hepatic cirrhosis ,alcoholic liver damage.

Different mechanisms of action of silymarin are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as silymarin has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of silymarin is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp), organic anion uptake transporter peptides (OATP), bile salt export pump, and TNF-α-dependent transporters.

Adult Dose: 1 to 3 capsule(s) should be taken into 2 to 3 times daily or medication should be continued until the relief of symptoms according to the advice of physician. Child Dose: It should not be given to children without advice of physician. Uses for below 12 years recommended after discussion with registered physician. Renal Dose: It should be used with caution in patients with kidney disease. Dose adjustment of Silymarin [Milk thistle] may be needed. Please consult your doctor.

Take Silymarin [Milk thistle] in the dose and duration as advised by your doctor. Take Silymarin [Milk thistle] orally with plenty of water. Do not chew, crush or break it.

If you forget to take yourSilymarin [Milk thistle] , take them as soon as you remember. If it is almost time for your next dose, skip the missed dose and take it at the usual time. Avoid taking two doses at the same time.

Sometimes it cause: • Mild digestive upset • Allergic reactions

[SAFE IF PRESCRIBED] Limited research on the effects of Silymarin [Milk thistle] on driving ability.

Contraindicated in patient with a known hypersensitivity to silymarin.

Concomitant use of silymarin and butyrophenones or phenothiazines has resulted in the reduction of lipid peroxidation.

[UNSAFE] It is unsafe to consume alcohol with Silymarin [Milk thistle].

[CONSULT YOUR DOCTOR] Silymarin [Milk thistle] is not recommended for use during pregnancy. Controlled, long-term safety studies are lacking. Please consult your doctor.

[CONSULT YOUR DOCTOR] No experience is available about the use of Silymarin [Milk thistle] .Long-term safety studies are lacking. Please consult your doctor.

[CAUTION] It should be used with caution in patients with kidney disease. Dose adjustment of Silymarin [Milk thistle] may be needed. Please consult your doctor. [CAUTION] It should be used with caution in patients with liver disease. Dose adjustment of Silymarin [Milk thistle] may be needed. Please consult your doctor.

Store in a cool & dry place, away from light & moisture. Keep out of reach of children.