HPC Injection250mg/ml

Hydroxyprogesterone Caproate is used to prevent premature labor in pregnant women in order to reduce the risk of giving birth too early (preterm birth). It prevents miscarriage and lower the risk of premature birth in women who have had one premature delivery in the past. Hydroxyprogesterone Caproate is administered only by or under the supervision of doctor. It should be taken as your doctor advice. Your doctor will decide how much you need to take and for how much time. You should take this injection for as long as it is prescribed for you. The most common side effects of this medicine include local site reactions at injection site, nausea, itching, diarrhea, and hives. If any of these bothers you, let your doctor know. There may be ways of reducing or preventing them. It may affect blood sugar levels, so monitor your blood sugar regularly. It is better to inform the doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain while using this medicine. Before taking this medicine inform doctor, if you have ever had any problems with your blood circulation or have diabetes, or any liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Hydroxyprogesterone Caproate is a progestin (female hormone). It works by modulating the immune response of the mother to prevent rejection of the embryo and allow its attachment to the uterus. This prevents miscarriage and helps lower the risk of premature birth in women who have had one premature delivery in the past.

• Premature Labor

Hydroxyprogesterone caproate stimulates luteal actions, changes in uterus and vagina as seen in early pregnancy. It also has prolonged uterotrophic effect. Contractile response of the myometrium to oxytocin is inhibited.

Adult Dose: Intramuscular Preterm Labor Indicated for prevention of preterm labor in a singleton pregnancy for patients aged 16 years or older who have a history of spontaneous preterm birth 250 mg IM qWeek Initiate between the 16th and 20th week of gestation and ending at the 37th week of gestation or birth (whichever is first) Recurrent miscarriage Adult: 250-500 mg wkly during the 1st half of pregnancy. Amenorrhoea; Abnormal uterine bleeding Adult: Single dose of 375 mg; may repeat at 4-wkly intervals if needed. After 4 days of desquamation, or if there is no bleeding within 21 days after admin of the drug, may initiate cyclic therapy that includes an oestrogen. For cyclic treatment (28-day cycle): Administer 20 mg of estradiol valerate on day 1, and on day 15, administer 250 mg of hydroxyprogesterone caproate and 5 mg of estradiol valerate. May repeat cyclic therapy at 4-wkly intervals as needed. Palliative treatment of advanced, inoperable endometrial carcinoma Adult: Usual dose: ?1 g, may repeat once or more times wkly. Usual range: 1-7 g/wk. Discontinue treatment if relapse occurs or if the objective response is not achieved after 12 wk of treatment. Hepatic Impairment Not studied; product is extensively metabolized in liver; potential for reduce elimination Child Dose: Safety and efficacy not established Renal Dose: Not studied in patients with renal impairment

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Nausea • Itching • Diarrhea • Hives • Nodules

[SAFE] Hydroxyprogesterone Caproate does not usually affect your ability to drive. Hydroxyprogesterone Caproate is used in pregnant women to help lower the risk of giving birth too early (preterm birth). It is only given to a woman who has had a preterm delivery in the past. It is not for use in women who are pregnant with more than one baby (twins, triplets, etc.). It is administered only by or under the immediate supervision of your doctor. Your doctor can start giving you the injection every week between 16 and 20 weeks and continue through week 37, or until you deliver. It may affect blood sugar levels. Monitor your blood sugar regularly. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. These could be symptoms of a serious liver problem. Inform your doctor immediately if you have pain in the chest, groin or legs, difficulty with breathing, sudden severe headache, slurred speech, sudden unexplained shortness of breath, a sudden loss of coordination, or vision changes while using this medicine.

Undiagnosed vaginal bleeding, breast cancer, pregnancy, lactation. Thrombophlebitis, thromboembolic disorders, cerebral apoplexy or a history of these conditions. Markedly impaired liver function.

Increased clearance when used with enzyme inducers e.g. carbamazepine and phenytoin. May inhibit metabolism of ciclosporin.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Hydroxyprogesterone Caproate. Please consult your doctor.

[SAFE IF PRESCRIBED] Hydroxyprogesterone Caproate is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Hydroxyprogesterone Caproate is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. Nonhormonal contraceptives are preferred in breastfeeding women, especially during the first 4 weeks postpartum

[CONSULT YOUR DOCTOR] There is limited information available on the use of Hydroxyprogesterone Caproate in patients with kidney disease. Please consult your doctor. This medicine contains progesterone which can cause fluid retention in patients with underlying kidney disease. [UNSAFE] Hydroxyprogesterone Caproate is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

Please tell me the brand names of projestron inj Proluton depot for supporting pregnancyDepot provera for contraception. Hello dr.i had miscarriage before 6 months it was my first baby now am 14th week pregnent, wanna ask you for how many months should I take progesteron 200 mg It is good till 14 weeks and after that for uterine relaxation take inj proluton depot weekly for two or three months My wife is pregnant so i want to consult about her problem . She is taking medicine duphaston,susten,revici,inj proluton depot 500,and lupi hcg 2000 These med are generally given in case of high risk pregnancy. These can be taken if required Aneuploidy scan done at 12 weeks. Choriodecidual bleed seen on left side. Area of blood 5cm 2. Rest all ok. Pls advice nothing can be done at present mam. this bleed will resolve atbits own. but u need to take restm u vl remail at risk of abortion and preterm pains. so in case of slightest bleed plz go to hospital. uou can take injection proluton depot 500 mg IM weekly till 20 weeks its just a supportive management. Primi with 3 uterine fibroids, on duphaston 10mg bid. Respected madam/sir I am an mbbs doctor, i m pregnant,primi, 4 months pregnant I have 3 uterine fibroids, posterior wall utero cervical junction(85.7*68.9mm), posterior wall fundal right lateral wall(30.9*25.3mm & My doctor says i will have to keep taking duphaston. I am having severe lower abdominal pain since 7days, my sonography is normal, blood and urine reports are normal as well. I would be extremely thankful if u would guide me. Thank u Rule out any fibroid degeneration. You can switch to proluton inj. Usually I prescribe Duphaston till 12 weeks only. I am 6 month pregnant I feel normal pain in lower abdomen and some time burning sensation when pass urine gynaecologist advice me tab nitrofrurotoin 100mg, inj proluton depot 500mg im ,inj tramadol 500 mg im yet i am not taking Plz advice me it is safe or any side effect Nitrofurantoin is for urinary infection. Get your urine R& M and C& S done. If there is any pus cells or infection on culture then take nitrofurantoin. Proluton and tramadol are fine. I am 19 weeks 4 days pregnant .My doctor earlier advised to take hocog5000 and proluton depot 250 injection.i am taking these injectons twice in a month.please suggest is it safe to take these injectons in 2nd trimester as I am already taking duphaston tablets twice daily Regards PATIENT These inj are given to support the pregnancy in high risk cases. Can be taken if required Our doctor was continously asking to take injection hcg and proluton every week. My wife is currently 14th week. She is taking injections from 7th week. Are they necessary? Also she is taking SUSTEN SR 300, aripreg sachets, folvite everyday. Hi I can suggest anthu