HPR DS 500

Mefenamic Acid is used in the treatment of moderate to severe pain conditions like menstrual pain, headache, muscle pain, joint pain or dental pain. It effectively alleviates pain and inflammation. Mefenamic Acid should be taken with food. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it. The most common side effects of this medicine include mild vomiting, stomach pain, nausea, headache, and dizziness. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. Before using it, you should let your doctor know if you have asthma, have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Pregnant and breastfeeding mothers should consult their doctors before using the medicine. Mefenamic Acid is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).

• Pain relief

Mefenamic acid, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties w/ minor anti-inflammatory activity.

Adult Dose: Oral Rheumatoid arthritis; Mild to moderate pain; Dental pain; Postoperative pain; Dysmenorrhoea; Osteoarthritis; Menorrhagia Adult: 250-500 mg upto 3 times daily for 3-7 days. Max. 1.5 gm total. Child Dose: Oral Rheumatoid arthritis; Mild to moderate pain; Dental pain; Postoperative pain; Dysmenorrhoea; Osteoarthritis; Menorrhagia Child: >6 mth 25 mg/kg daily in divided doses for up to 7 days.

Take this medicine in the dose and duration as advised by your doctor. Dissolve it in a glass of water before taking it. Mefenamic Acid is to be taken with food.

Common: • Vomiting • Nausea • Indigestion • Diarrhea • Loss of appetite

[UNSAFE] Mefenamic Acid may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. It should be taken with food or milk to avoid getting an upset stomach. It can cause serious complications like stomach bleeding and kidney problems if taken for a long time. Meftal 250mg Tablet DT can raise your risk of blood clots, heart attack, or a stroke. Inform your doctor if you are pregnant or planning to conceive or breastfeeding. Inform your doctor if you have ever been diagnosed with kidney or liver problems.

Hypersensitivity to mefenamic acid, aspirin or other NSAIDs. Patient w/ inflammatory bowel disease, active ulceration or chronic inflammation of the upper or lower GI tract, renal failure. History of asthma, urticaria, allergic-type reactions. Treatment of perioperative pain in the setting of CABG surgery, pregnancy (3rd trimester), lactation. Coronary artery bypass graft surgery, severe renal impairment, severe heart failure.

Concomitant use w/ CYP2C9 isoenzyme inhibitors may alter safety and efficacy of mefenamic acid. May enhance methotrexate toxicity. Reduced BP response to ACE inhibitors or angiotensin II receptor antagonists. Increased risk of serious GI events w/ aspirin. May reduce the natriuretic effects of furosemide or thiazide diuretics. Reduced renal lithium clearance and elevated plasma lithium levels. May enhance anticoagulant effect of warfarin.

[UNSAFE] It is unsafe to consume alcohol with Mefenamic Acid.

[CONSULT YOUR DOCTOR] Mefenamic Acid may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Mefenamic Acid is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

[CAUTION] Mefenamic Acid should be used with caution in patients with kidney disease. Dose adjustment of Mefenamic Acid may be needed. Please consult your doctor. Use of Mefenamic Acid is not recommended in patients with severe kidney disease. [CAUTION] Mefenamic Acid should be used with caution in patients with liver disease. Dose adjustment of Mefenamic Acid may be needed. Please consult your doctor.

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