৳ 2/unit
Pack: ৳ 2
৳ 2/unit
Pack: ৳ 2
At a glance
Hydroxyzine Hydrochloride is an antihistamine used to treat symptoms of skin allergy like itching, swelling, and rashes, as well as anxiety.
Indications
- Symptomatic relief of anxiety and tension (associated with psychoneurosis)
- Pruritus due to allergic conditions (chronic urticaria, atopic and contact dermatoses)
- Sedative (premedication and following general anesthesia)
Pharmacology
Hydroxyzine Hydrochloride is an anxiolytic antihistamine of the piperazine class which is a H1 receptor antagonist. It is not a cortical depressant, but its action may be due to a suppression of activity in certain key regions of the subcortical area of the central nervous system. It is rapidly absorbed from the gastrointestinal tract and clinical effects are usually noted within 15 to 30 minutes after oral administration.
Dosage
Adult Dose (Oral):
- Anxiety & Tension: 50-100 mg 4 times daily
- Pruritus (Allergic): Initial: 25 mg at night; may increase up to 25 mg 3-4 times daily
- Sedative (Premedication): 50-100 mg
- Hepatic Impairment: Reduce total daily dose by 33%
Child Dose (Oral):
- Anxiety (under 6 years): 50 mg daily in divided doses; (>6 years): 50-100 mg daily in divided doses
- Pruritus (6 mo-6 yr): Initial 5-15 mg/day, increased to 50 mg/day; (>6 yr): 15-25 mg/day, up to 50-100 mg/day
- Sedative: 0.6 mg/kg
- Hepatic Impairment: Reduce total daily dose by 33%
Renal Dose: CrCl >50 mL/min: No adjustment; <50 mL/min: Administer 50% normal dose
Side effects
Common Side Effects:
- Sedation
- Nausea
- Vomiting
- Upset stomach
- Constipation
- Diarrhea
- Loss of appetite
Others: Headache, psychomotor impairment, antimuscarinic effects (urinary retention, dry mouth, blurred vision), hypotension, palpitation, arrhythmias, extrapyramidal effects, dizziness, confusion, depression, sleep disturbances, tremor, seizures
Use in pregnancy
Use in Pregnancy: Safety in early pregnancy not established; contraindicated in early pregnancy.
Precautions & warnings
Precautions:
- Hydroxyzine may decrease alertness; do not drive or operate machinery
- Avoid alcohol (may cause excessive sleepiness)
- Inform doctor if you have heart disease (may increase risk of heart problems)
- Inform doctor if you have kidney or liver problems
- With CNS depressants, dosage should be reduced
- Avoid concomitant use with MAO inhibitors
Overdose effects
Overdose: Most common manifestation is hypersedation; induce vomiting or gastric lavage; general supportive care; hypotension may be controlled with IV fluids and Levarterenol or Metaraminol; do not use Epinephrine (hydroxyzine counteracts its pressor action); no specific antidote.
Storage conditions
Store in a cool & dry place; protect from light; keep out of reach of children.