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At a glance

Pilocarpine Hydrochloride is a cholinergic agonist used for the treatment of dry mouth after radiotherapy of head and neck cancer. It increases the production of saliva, tears, sweat, digestive juices, and other secretions, making speaking and swallowing easier.

Indications
  • Dry mouth after radiotherapy of head and neck cancer
Pharmacology

Pilocarpine is a cholinergic agonist that activates muscarinic receptors. It stimulates exocrine glands such as salivary glands, lacrimal glands, sweat glands, and digestive glands. It increases saliva production by providing compensatory stimulation to salivary glands after head and neck radiotherapy.

Dosage

Adult Dose (Oral):

  • Dry mouth: Dose and duration as advised by the doctor
  • May be taken with or without food; take at a fixed time
Side effects

Common Side Effects:

  • Excessive sweating
  • Frequent urge to urinate
  • Chills
Use in pregnancy

Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May decrease alertness, affect vision, or cause sleepiness and dizziness; do not drive if these occur
  • Caution during pregnancy and lactation
  • Caution in kidney and liver disease
  • Not recommended in severe liver disease
Overdose effects

Overdose: Excessive cholinergic stimulation; bradycardia, hypotension, respiratory depression; treatment: Atropine (cholinergic antagonist), symptomatic supportive care.

Storage conditions

Store in a cool and dry place, away from light; keep out of reach of children.

Pilocarpine Hydrochloride — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.