osudhkosh
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Company•Incepta Pharmaceuticals Ltd.

Incotim

800mg+160mgRx
Generic: Sulphamethoxazole + Trimethoprim (Co-trimoxazole)

৳ 1.50/unit

Pack: ৳ 1.50

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At a glance

Co-trimoxazole (Sulphamethoxazole + Trimethoprim) is a combination antibiotic used for pneumonia, bronchitis, urinary tract, ear, and abdominal bacterial infections. It works by blocking two steps in bacterial folic acid production.

Indications
  • Respiratory tract infections (bronchitis, bronchiectasis, pneumonia, sinusitis, otitis media)
  • Urinary tract infections (cystitis, pyelonephritis, prostatitis, gonorrhea)
  • Gastrointestinal infections (Salmonella, Shigella)
  • Peritonitis
  • Pneumocystis jiroveci pneumonia (PCP)
Pharmacology

Co-trimoxazole provides sequential blockade of two steps in the bacterial folic acid synthesis pathway. Sulphamethoxazole inhibits dihydropteroate synthetase; Trimethoprim inhibits dihydrofolate reductase. This synergistic action stops bacterial protein and nucleic acid synthesis, producing bactericidal effects.

Dosage

Adult Dose (Oral):

  • Moderate infections: 2 tablets (480 mg) twice daily
  • Severe infections: 2 tablets three times daily
  • DS tablet: 1 tablet (960 mg) twice daily
  • PCP: 120 mg/kg/day in 2-4 divided doses for 14-21 days

Pediatric Dose (Oral):

  • 6-12 years: 2 teaspoonfuls syrup twice daily
  • 6 months-5 years: 1 teaspoonful twice daily
  • 6 weeks-6 months: 0.5 teaspoonful twice daily
Side effects

Common Side Effects:

  • Nausea, vomiting
  • Skin rash
  • Allergic reactions
  • Diarrhea

Serious (Rare):

  • Crystalluria
  • Hemolysis, thrombocytopenia
  • Neutropenia, agranulocytosis
Use in pregnancy

Use in Pregnancy: Unsafe (Category D); evidence of risk to developing baby; use only in life-threatening situations; consult your doctor.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Do not use in hypersensitivity to sulfonamides or trimethoprim
  • Do not use in severe liver failure, jaundice, severe renal impairment
  • Do not use in porphyria, megaloblastic anemia
  • Do not use in pregnancy and neonates (4 weeks)
Overdose effects

Overdose may cause nausea, vomiting, headache, confusion; provide symptomatic treatment; hemodialysis is effective.

Storage conditions

Store below 30°C, away from light and moisture; keep out of reach of children.

Sulphamethoxazole + Trimethoprim (Co-trimoxazole) — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.