৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Indacaterol Maleate is used for long-term maintenance bronchodilator treatment of airflow obstruction in patients with COPD.
Indications
- Long-term maintenance bronchodilator treatment of airflow obstruction in COPD patients (including chronic bronchitis and/or emphysema)
Pharmacology
Indacaterol is a long-acting β2-adrenergic agonist that stimulates intracellular adenyl cyclase, catalyzing conversion of ATP to cyclic AMP. Increased cyclic AMP levels cause relaxation of bronchial smooth muscle. When inhaled, indacaterol acts locally in the lung as a bronchodilator. It is more than 24-fold more potent at beta2-receptors compared to beta1-receptors.
Dosage
Adult Dose (Inhalation):
- Recommended dose: Inhale contents of one 75 mcg, 150 mcg, or 300 mcg capsule once daily using device
- Max: 300 mcg once daily
- Do not swallow capsules
Geriatric: No dosage adjustment required
Renal Impairment: No dosage adjustment required
Hepatic Impairment: Mild-moderate: No adjustment; severe: No data available
Child Dose: Safety and efficacy not established
Side effects
Most Common:
- Cough
- Nasopharyngitis
- Headache
- Nausea
- Oropharyngeal pain
- Runny nose
- Dizziness
Others: Hypersensitivity reactions, paradoxical bronchospasm, tachycardia, pruritus
Use in pregnancy
Use in Pregnancy: Category C; no adequate and well-controlled studies; use only if potential benefit justifies potential risk to fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- LABA monotherapy increases risk of serious asthma-related events
- Not approved for asthma; do not use in asthma patients (without long-term control medication)
- Do not use to treat acute symptoms
- If paradoxical bronchospasm occurs, discontinue
- Caution in cardiovascular disorders, convulsive disorders, thyrotoxicosis, diabetes mellitus
- Caution with MAO inhibitors, tricyclic antidepressants or drugs that prolong QT interval
Overdose effects
Overdose: May cause angina, hypertension or hypotension, tachycardia (up to 200 bpm), arrhythmias, nervousness, headache, tremor, dry mouth, palpitations, muscle cramps, nausea, dizziness, fatigue, hypokalemia, hyperglycemia, metabolic acidosis, insomnia; cardiac arrest and death may occur.
Storage conditions
Capsules must always be stored in blister and removed immediately before use; store in a cool & dry place; keep out of reach of children.