৳ 60/unit
Pack: ৳ 60
৳ 60/unit
Pack: ৳ 60
At a glance
Hydrocortisone is a corticosteroid used for severe allergic reactions, allergic conditions, cancer, skin and eye disorders, and adrenal insufficiency.
Indications
- Primary or secondary adrenocortical insufficiency
- Acute adrenocortical insufficiency
- Shock unresponsive to conventional therapy
- Congenital adrenal hyperplasia
- Hypercalcemia associated with cancer
- Nonsuppurative thyroiditis
- Rheumatic Disorders
- Dermatologic Diseases (Allergic States, Severe seborrheic dermatitis, Severe psoriasis, Pemphigus, Severe erythema multiforme)
- Severe allergic conditions (Bronchial asthma, Contact dermatitis, Atopic dermatitis, Serum sickness, Allergic rhinitis, Drug hypersensitivity, Urticarial transfusion reactions, Acute noninfectious laryngeal edema)
- Ophthalmic Diseases (Herpes zoster ophthalmicus, Iritis, Iridocyclitis, Chorioretinitis, Diffuse posterior uveitis, Optic neuritis)
- Gastrointestinal Diseases
- Hematologic Disorders (Autoimmune hemolytic anemia, Idiopathic thrombocytopenic purpura, Secondary thrombocytopenia, Erythroblastopenia)
- Neoplastic Diseases (Leukemias and lymphomas, Acute leukemia of childhood)
- Edematous States
- Acute exacerbations of multiple sclerosis
Pharmacology
Hydrocortisone inhibits prostaglandin synthesis by inhibiting the enzyme phospholipase A2. It reduces various vasoactive agents released during inflammation and controls the rate of protein synthesis. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability.
Dosage
Adult Dose (Oral):
- Initial dosage: 20-240 mg daily depending on disease
- Replacement therapy in adrenocortical insufficiency: 20-30 mg daily in 2 divided doses
Adult Dose (Injection):
- Acute adrenocortical insufficiency: 100-500 mg 3-4 times/24 hr
- Supplement during anesthesia: 25-50 mg at induction
- Status Asthmaticus: 1-2 mg/kg IV q6hr for 24 hr; maintenance: 0.5-1 mg/kg q6hr
- Intra-articular: 5-50 mg depending on joint size
Child Dose (Injection):
- Acute adrenocortical insufficiency: <1 yr: 25 mg; 1-5 yr: 50 mg; 6-12 yr: 100 mg
- Status Asthmaticus: 1-2 mg/kg IV q6hr for 24 hr; not to exceed 250 mg IV; maintenance: 2 mg/kg/day IV divided q6hr
Side effects
Common Side Effects:
- Ankle swelling
- Dizziness
- Headache
- Weakness
With prolonged high doses:
- Cardiac arrhythmia
- Esophageal candidiasis
- Menstrual irregularity
- Decreased carbohydrate & glucose tolerance
- Fluid retention
- Weight gain
- Euphoria, mood swings, depression, insomnia, acne
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies have shown harmful effects; use only if absolutely required.
Precautions & warnings
Precautions:
- Caution in history of peptic ulceration (increases incidence of peptic ulceration)
- Caution in congestive heart failure, hypertension, glaucoma, diabetes mellitus and epilepsy
- Tell doctor if you have signs of infection (fever or sore throat)
- Do not stop suddenly without talking to your doctor (may worsen symptoms)
- Withdraw gradually after long-term therapy
Overdose effects
Overdose: Acute toxicity from corticosteroid overdose is rare; chronic overdose may cause Cushing's syndrome; symptomatic treatment.
Storage conditions
Store below 30°C temperature, away from light & moisture; keep out of reach of children.