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Irinacan 40 IV Infusion20mg/ml

OTC
Generic:
Irinotecan Hydrochloride Trihydrate
Company:
Renata Limited
Dosage form:
Injection
Pack size:
40mg Vial
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৳ 1,800/unit

Pack: ৳ 1,800

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At a glance

Irinotecan Hydrochloride Trihydrate is used for the treatment of colon and rectal cancer, as first-line therapy in combination with 5-fluorouracil and leucovorin, or as second-line therapy after failure of fluorouracil-based therapy.

Indications
  • Metastatic colorectal cancer (first-line with 5-fluorouracil and leucovorin)
  • Metastatic colorectal cancer after failure of fluorouracil-based therapy
Dosage

Adult Dose (IV Infusion):

  • Combination Therapy (Weekly): 125 mg/m2 (90 min infusion) on days 1, 8, 15, 22; then 2 weeks off
  • Combination Therapy (Every 3 Weeks): 350 mg/m2 (30-90 min infusion) every 3 weeks
  • Combination Therapy (6-week cycle, infusional 5-FU/LV): 180 mg/m2 on days 1, 15, 29
  • Combination Therapy (6-week cycle, bolus 5-FU/LV): 125 mg/m2 on days 1, 8, 15, 22

Child Dose: Not recommended

Side effects

Common Side Effects (>30%):

  • Nausea, vomiting
  • Abdominal pain
  • Diarrhea (early and late)
  • Constipation
  • Anorexia
  • Mucositis
  • Neutropenia, leukopenia
  • Anemia, thrombocytopenia
  • Asthenia, pain, fever, infection
  • Alopecia

Serious: Grade 3-4 late diarrhea (23-31%), neutropenic fever (3%), sepsis

Precautions & warnings

Precautions:

  • Irinotecan may decrease alertness, affect vision or make you feel sleepy and dizzy; do not drive if symptoms occur
  • Early diarrhea (during or shortly after infusion): transient; prevent/treat with atropine
  • Late diarrhea (>24 hours): can be life-threatening; may lead to dehydration, electrolyte imbalance, or sepsis
  • Myelosuppression: deaths due to sepsis following severe neutropenia reported
  • Patients homozygous for UGT1A1*28 allele are at increased risk for neutropenia
Irinotecan Hydrochloride Trihydrate — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.