Irinotecan PhaRes20mg/ml

Irinotecan Hydrochloride Trihydrate is used in the treatment of cancer of colon and rectum. It shows its working by stopping or slowing down the growth of cancer cells. Irinotecan Hydrochloride Trihydrate is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include fatigue, nausea, vomiting, weakness, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, sore throat, and continuous episodes of diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Irinotecan Hydrochloride Trihydrate is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.

• Cancer of colon and rectum

Irinotecan, a derivative of camptothecin, works by inhibiting the enzyme topoisomerase I thereby interfering with the coiling and uncoiling of DNA during replication and causing irreparable damage.

Adult Dose: Intravenous Colorectal Cancer Indicated as first-line therapy (with 5-fluorouracil and leucovorin) for metastatic colorectal cancer (CRC); it is also indicated for CRC that has recurred or progressed following intial fluorouracil-based therapy Monotherapy Patients should be premedicated with antiemetic agents Atropine treatment should be considered in patients that experience cholinergic symptoms Regimen 1 (Weekly): 125 mg/m² IV infusion over 90 minutes on days 1, 8, 15, 22, then 2 weeks off, then repeat Regimen 2 (Once Every 3 Weeks): 350 mg/sq.meter IV infusion over 30-90 minutes q3Weeks Adjust dose per protocol Combination therapy Patients should be premedicated with antiemetic agents Atropine treatment should be considered in patients that experience cholinergic symptoms Regimen 1 (6 week cycle with infusional 5-fluorouracil/ leucovorin): 180 mg/m² IV infusion over 30-90 minutes once on days 1, 15, and 29 IV (infuse over 30-90 min), followed by infusion with leucovorin and 5-fluorouracil; next cycle begins on day 43 Regimen 2 (6 week cycle with bolus 5-fluorouracil/ leucovorin): 125 mg/sq.meter on days 1, 8, 15, and 22 (infuse over 90 min), followed by bolus doses of leucovorin and 5-fluorouracil Adjust dose per protocol Hepatic impairment: Dose reduction may be necessary. Child Dose: Not recommended

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Irinotecan Hydrochloride Trihydrate, please consult your doctor.

Common: • Fatigue • Nausea • Vomiting • Weakness • Hair loss • Fever • Anemia (low number of red blood cells) • Diarrhea • Decreased white blood cell count (neutrophils) • Decreased appetite • Mucosal inflammation

[UNSAFE] Irinotecan Hydrochloride Trihydrate may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Irinotecan Hydrochloride Trihydrate is used in combination with other medicines for the treatment of metastatic cancer of the colon and rectum. It is given via a drip into a vein (intravenous infusion). It may cause dizziness and visual disturbances. Do not drive or do anything that requires mental focus until you know how it affects you. Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine. Your doctor may get regular blood tests done to monitor your blood cells, kidney and liver function during treatment with this medicine. Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash. Inform your doctor if you notice passage of blood in stools or experience dizziness or faintness, continuous episodes of nausea, vomiting, diarrhea or fever.

Patients with a known hypersensitivity to the drug or its excipients.

Diuretics increase risks of dehydration secondary to vomiting/diarrhoea; prophylactic dexamethasone as an antiemetic may enhance lymphocytopenia; prochlorperazine may increase incidence of akathisia; antineoplastic agents (myelosuppression and diarrhoea). St John's wort, ketoconazole may reduce irinotecan exposure.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Irinotecan Hydrochloride Trihydrate. Please consult your doctor.

[CONSULT YOUR DOCTOR] Irinotecan Hydrochloride Trihydrate is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Irinotecan Hydrochloride Trihydrate is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[SAFE IF PRESCRIBED] Irinotecan Hydrochloride Trihydrate is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Irinotecan Hydrochloride Trihydrate may not be needed in these patients. Please consult your doctor. Use of this medicine is not recommended for patients on dialysis. [CONSULT YOUR DOCTOR] There is limited information available on the use of Irinotecan Hydrochloride Trihydrate in patients with liver disease. Please consult your doctor.

Is ulcers curable G2 stage of cancer in rectum area Needs evaluation Please meet a Gastro surgeon My dad is suffering from colon cancer How to get rid of it Surgery is main stay of treatment, which should be followed by chemotherapy. Colon cancer What treat many I have to give Complete reports along with the patient is need to be seen before starting the treatment I hv phobia of cancer plzzzzzz I m suffering from mild stomach pain change in bowel movement and lack of apputite and i m depressed to thik about that it s a some type of cancer like stonach cancer or colon cancer All day i think about cancer in my body You need psychological counseling Diagnosed with colon cancer 30 by 40 mm. There is also lump near liver, how ever it could not be verified whether it is benign or malign. Please suggest the way to diagnose the tumour near liver and also the treatment and cost to cure colon cancer Do only pet scan , it will guide.Needs chemotherapy followed by surgery What are the home remedies on Colone cancer? no as such home remedy to treat colon cancer, case has to be first seen, before prescribing medicine. Giloy ras. wheat grass juice, aamal ras, neem ras, cow urine , each 20 ml twice is helpful