Irofol

• Iron Deficiency Anemia: Used for treatment and prevention of iron deficiency anemia.
• Chronic Hemodialysis: Used as iron supplement with erythropoietin treatment.

Ferrous fumarate is an iron preparation that is used in the prevention and treatment of iron deficiency. The amount of elemental iron is 330 mg/g of ferrous fumarate. Iron is an essential component in the formation of hemoglobin; adequate amounts of iron are necessary for effective erythropoiesis.

Adult Dose (Oral):

• Iron Deficiency Treatment: 150-200 mg Fe (elemental iron)/day PO; may administer 60-100 mg elemental iron q12hr or up to 60 mg elemental iron q6hr.
• Iron Deficiency Prophylaxis: 60-100 mg Fe (elemental iron)/day PO.

Child Dose (Oral): As syrup containing 100 mg/5ml; preterm neonate: 0.6-2.4 ml/kg daily; up to 6 yr: 2.5-5 ml bid.

Common Side Effects:

• Constipation
• Diarrhea
• Dark stools
• Dizziness
• Headache
• Nausea
• Heartburn
• Epigastric pain

Use in Pregnancy: Pregnancy Category: not available; pregnant women typically require increased iron ingestion (see dosing sections).

Precautions:

• Patients with intestinal strictures and diverticular disease: caution.
• May worsen diarrhea in patients with inflammatory bowel disease.
• May cause constipation and fecal impaction in elderly.
• Avoid prolonged administration (>6 months) except in patients with continued bleeding, menorrhagia or repeated pregnancies.
• Not for routine use in treatment of hemolytic anemia unless iron-deficient state exists.
• Parenteral iron should not be used concurrently with oral iron treatment.
• Avoid use in patients receiving repeated blood transfusions.

Overdose: Iron overdosage is dangerous, especially in children; gastric lavage and desferrioxamine should be administered.

Storage: Keep below 30 degree C, away from light and moisture. Keep out of reach of children.