৳ 650/unit
Pack: ৳ 650
৳ 650/unit
Pack: ৳ 650
At a glance
Ketoconazole is an antifungal medication used for the treatment of fungal skin infections, seborrheic dermatitis, dandruff, and pityriasis versicolor.
Indications
- Fungal skin infections (tinea pedis, tinea corporis, tinea cruris)
- Seborrheic dermatitis
- Dandruff (pityriasis capitis)
- Pityriasis versicolor
- Vaginal candidiasis
- Other systemic mycoses
Pharmacology
Ketoconazole interacts with 14-α-sterol demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability due to reduced amounts of ergosterol in the fungal cell membrane. This metabolic inhibition also results in accumulation of 14α-methyl-3,6-diol, a toxic metabolite.
Dosage
Adult Dose (Shampoo):
- Seborrheic dermatitis/Dandruff: twice weekly × 2-4 weeks (treatment); once every 1-2 weeks (prophylaxis)
- Pityriasis versicolor: once daily × 5 days
Adult Dose (Cream):
- Tinea pedis: twice daily × 1 week (mild); more severe until symptoms resolve
- Other infections: once or twice daily; tinea versicolor 2-3 weeks; tinea corporis 3-4 weeks
Adult Dose (Tablet):
- Vaginal candidiasis: 200 mg twice daily × 5 days
- Other: 200 mg once daily until 1 week after symptoms resolve
Child Dose (Tablet): 3.3-6.6 mg/kg/day once daily
Side effects
Shampoo:
- Local burning sensation
- Itching
- Contact dermatitis
- Oily and dry hair (rare)
Cream:
- Application site burning
- Erythema
- Pruritus
- Skin exfoliation
- Dry skin
Tablet:
- Nausea
- Headache
- Diarrhea
- Abdominal pain
- Vomiting
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies have shown harmful effects; doctor will weigh benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- After prolonged topical corticosteroid use, gradually withdraw over 2-3 weeks (to prevent rebound effect)
- If shampoo gets into eyes, bathe with water
- Not for ophthalmic use (cream)
- Monitor liver enzymes in patients with previous liver disease (tablet)
- Discontinue tablet if signs of liver reaction (nausea, fatigue, pale stools, dark urine, jaundice)
Overdose effects
Overdose (Shampoo/Cream): Topical overdose may cause erythema, edema and burning sensation; resolves upon discontinuation; accidental ingestion requires no special measures.
Storage conditions
Keep below 25°C temperature, away from light & moisture; keep out of reach of children.