osudhkosh
New
Company•Globe Pharmaceuticals Ltd.

Kanaquine

300mgRx
Generic: Quinine Sulphate

৳ 6.40/unit

Pack: ৳ 64

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At a glance

Quinine Sulphate is a cinchona alkaloid and 4-methanolquinoline used for uncomplicated, severe, and complicated falciparum malaria, falciparum malaria resistant to other drugs, and prevention of nocturnal muscle cramps.

Indications
  • Uncomplicated, severe, and complicated falciparum malaria
  • Falciparum malaria resistant to other drugs
  • Prevention of nocturnal muscle cramps
Pharmacology

Quinine suppresses the asexual cycle of malaria parasites by interfering with lysosomal function or nucleic acid synthesis in Plasmodia spp. It is a highly active blood schizonticide and prevents parasite development.

Dosage

Adult Dose (Oral):

  • Malaria (sulfate): 648 mg every 8 hours for 7 days
  • Nocturnal leg cramps: 200-300 mg once at night

Pediatric Dose (Oral):

  • Malaria (sulfate): >8 years: 10 mg/kg every 8 hours for 7 days

Pregnancy: Adult treatment doses can be safely used

Severe Renal Impairment: Initially 648 mg, followed after 12 hours by 324 mg every 12 hours

Side effects

Side Effects (Cinchonism):

  • Severe headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Blurred vision
  • Tinnitus
  • Flushing of skin
  • Fever
  • Rash
  • Pruritus
  • Hypoglycemia
  • Hemolysis in G6PD deficiency
  • Thrombocytopenia
  • Hepatitis
  • Potentially fatal: Sinus arrest, AV block, ventricular fibrillation, sudden death
Use in pregnancy

Use in Pregnancy: Safe in therapeutic doses during pregnancy; limited information on fetal risk.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Caution in patients with cardiac conduction defects, heart block, or atrial fibrillation
  • Monitor for cardiotoxicity, blood glucose, CBC, LFT, ECG
  • Caution in prolonged QT interval, tinnitus, optic neuritis, myasthenia gravis
  • Caution in pregnancy and lactation
Overdose effects

Overdose: Exacerbation of cinchonism (nausea, vomiting, tinnitus, visual disturbances), cardiac arrhythmias; treatment: symptomatic supportive care, gastric lavage, electrolyte monitoring.

Storage conditions

Store away from light and moisture; keep out of reach of children.

Quinine Sulphate — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.