৳ 200/unit
Pack: ৳ 200
৳ 200/unit
Pack: ৳ 200
At a glance
Potassium Citrate is used for the treatment of renal tubular acidosis (RTA) with calcium stones, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones. It alkalinizes urine and citrate binds with urinary calcium, preventing stone formation.
Indications
- Renal tubular acidosis (RTA) with calcium stones
- Hypocitraturic calcium oxalate nephrolithiasis
- Uric acid lithiasis with or without calcium stones
Pharmacology
Potassium Citrate administration produces an alkaline load through metabolism of absorbed citrate, increasing urinary pH and citrate. Citrate complexes with calcium, decreasing calcium ion activity and calcium oxalate saturation, and inhibits spontaneous nucleation of calcium oxalate and calcium phosphate. The rise in urinary pH also increases ionization of uric acid to the more soluble urate ion.
Dosage
Adult Dose (Oral):
- Severe hypocitraturia (urinary citrate <150 mg/day): 60 mEq/day (30 mEq twice daily or 20 mEq three times daily, with meals or within 30 minutes after)
- Mild-moderate hypocitraturia (urinary citrate >150 mg/day): 30 mEq/day (15 mEq twice daily or 10 mEq three times daily)
- Maintenance: Titrate to achieve urinary citrate 320-640 mg/day & urinary pH 6.0-7.0 (max 100 mEq/day)
Side effects
Side Effects:
- Abdominal discomfort
- Vomiting
- Diarrhea
- Loose bowel movements
- Nausea
- Hyperkalemia
Use in pregnancy
Use in Pregnancy: Animal reproduction studies not conducted; use only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Hyperkalemia: Contraindicated in chronic renal failure, uncontrolled DM, acute dehydration, adrenal insufficiency, extensive tissue breakdown
- Gastrointestinal lesions: Discontinue if severe vomiting, abdominal pain, or GI bleeding occurs; investigate for bowel perforation or obstruction
Overdose effects
Overdose: Hyperkalemia (usually asymptomatic; manifested by EKG changes); treatment: discontinue potassium-containing medications/foods, IV calcium gluconate, IV dextrose + insulin, sodium bicarbonate, hemodialysis/peritoneal dialysis.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.