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Oral Solution200ml Bottle
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At a glance

Potassium Citrate is used for the treatment of renal tubular acidosis (RTA) with calcium stones, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones. It alkalinizes urine and citrate binds with urinary calcium, preventing stone formation.

Indications
  • Renal tubular acidosis (RTA) with calcium stones
  • Hypocitraturic calcium oxalate nephrolithiasis
  • Uric acid lithiasis with or without calcium stones
Pharmacology

Potassium Citrate administration produces an alkaline load through metabolism of absorbed citrate, increasing urinary pH and citrate. Citrate complexes with calcium, decreasing calcium ion activity and calcium oxalate saturation, and inhibits spontaneous nucleation of calcium oxalate and calcium phosphate. The rise in urinary pH also increases ionization of uric acid to the more soluble urate ion.

Dosage

Adult Dose (Oral):

  • Severe hypocitraturia (urinary citrate <150 mg/day): 60 mEq/day (30 mEq twice daily or 20 mEq three times daily, with meals or within 30 minutes after)
  • Mild-moderate hypocitraturia (urinary citrate >150 mg/day): 30 mEq/day (15 mEq twice daily or 10 mEq three times daily)
  • Maintenance: Titrate to achieve urinary citrate 320-640 mg/day & urinary pH 6.0-7.0 (max 100 mEq/day)
Side effects

Side Effects:

  • Abdominal discomfort
  • Vomiting
  • Diarrhea
  • Loose bowel movements
  • Nausea
  • Hyperkalemia
Use in pregnancy

Use in Pregnancy: Animal reproduction studies not conducted; use only if clearly needed.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Hyperkalemia: Contraindicated in chronic renal failure, uncontrolled DM, acute dehydration, adrenal insufficiency, extensive tissue breakdown
  • Gastrointestinal lesions: Discontinue if severe vomiting, abdominal pain, or GI bleeding occurs; investigate for bowel perforation or obstruction
Overdose effects

Overdose: Hyperkalemia (usually asymptomatic; manifested by EKG changes); treatment: discontinue potassium-containing medications/foods, IV calcium gluconate, IV dextrose + insulin, sodium bicarbonate, hemodialysis/peritoneal dialysis.

Storage conditions

Store below 30°C, away from light and moisture; keep out of reach of children.

Potassium Citrate — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.