Kdrin 5
Rx- Generic:
- Procyclidine Hydrochloride
- Company:
- Opsonin Pharma Limited
- Dosage form:
- Tablet
- Pack size:
- Strip (10 Tablet)
৳ 1/unit
Pack: ৳ 10
At a glance
Procyclidine Hydrochloride — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Procyclidine Hydrochloride is a prescription medicine used in the treatment of Parkinson's disease and drug induced abnormal movements. It helps by improving muscle control and reducing the stiffness of the muscle, so that they can move easily. Procyclidine Hydrochloride should be taken with food as it reduces the side effects with this medicine. It should be taken at the same time each day, this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may result in a worsening of symptoms. Some common side effects of this medicine include nausea, vomiting, constipation, and blurred vision. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Dry mouth may occur commonly while using this medicine so, try to do frequent mouth rinses, maintain good oral hygiene, and increase water intake. Avoid wearing contact lenses as it may cause dry eyes as well. It is important to inform your doctor if you suffer from glaucoma or have trouble passing urine. Before using Procyclidine Hydrochloride, you should tell your doctor if you've ever had heart problems, problems with passing urine, liver or kidney disease. It may also affect, or be affected by, some other drugs you are using so let your doctor know what these are to be safe. Pregnant or breastfeeding mothers should consult their doctor before starting treatment with this medicine. Procyclidine Hydrochloride is a muscle relaxing medication. It works by decreasing the activity of excess acetylcholine in the brain. This improves muscle control and reduces stiffness. It helps patients with Parkinson's disease by improving muscle control and reducing stiffness so that they can move more naturally. It is also used to treat movement disorder (restlessness, involuntary movements or muscle spasm ) which can be caused by certain drugs.
Indications
• Parkinson's disease
Mechanism of action
Procyclidine is a tertiary amine antimuscarinic which acts by blocking excess acetylcholine at cerebral synapses. It also exhibits direct antispasmodic effect on smooth muscle.
Dosage
Adult Dose: Oral Parkinsonism and drug-induced extrapyramidal syndrome Adult: As hydrochloride: Initially, 2.5 mg tid, increased gradually by 2.5-5 mg every 2-3 days if required. Maintenance: 10-30 mg/day in 3-4 divided doses. Up to 60 mg daily may be required in some cases. Parenteral Parkinsonism and drug-induced extrapyramidal syndrome Adult: Emergency cases: IV admin: 5-10 mg, higher doses may be needed; IM admin: 5-10 mg as a single dose, may repeat after 20 minutes if needed, to a max of 20 mg daily. Elderly: Lower doses are required. Child Dose: Oral Dystonia in children Child: 7-12 yr: 1.25 mg tid; 12-18 yr: 2.5 mg tid. For emergency cases, a single dose may be given via IM or IV inj: <2 yr: 0.5-2 mg; 2-10 yr: 2-5 mg and 10-18 yr: 5-10 mg.
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Procyclidine Hydrochloride is to be taken with food.
Side effects
Common: • Dryness in mouth • Nausea • Vomiting • Constipation • Blurred vision • Dizziness • Lightheadedness • Dilatation of pupil • Upper abdominal pain • Urinary retention
Precautions & warnings
[UNSAFE] Procyclidine Hydrochloride may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Procyclidine Hydrochloride helps treat Parkinson's disease and drug-induced abnormal movements. Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help. It may cause dry eyes. Avoid wearing contact lenses and inform your doctor if it bothers you. It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. Inform your doctor if you suffer from glaucoma or if you have trouble passing urine. Do not stop taking Procyclidine Hydrochloride without talking to your doctor first as that may cause worsening of symptoms. Monitoring of intraocular pressure is required while taking this medicine, as an increase in eye pressure may cause blurry vision. You may be asked for regular monitoring of hypotension, kidney, liver, and cardiac disorder while taking this medicine.
Contraindications
Urinary outflow obstruction, prostatic hyperthrophy, narrow-angle glaucoma, paralytic ileus and pyloric stenosis.
Drug interactions
Increased plasma concentrations w/ paroxetine. Enhanced anticholinergic action w/ MAOIs and other anticholinergic drugs. Reduced therapeutic effect w/ cholinergic drugs. May antagonise the effect of parasympathomimetic agents. May reduce the absorption and therapeutic effect of sublingual or buccal nitrate tab. May reduce the efficacy of levodopa. May antagonise the GI effects of cisapride, domperidone and metoclopramide. May potentiate the vagolytic effects of quinidine. May reduce the absorption of ketoconazole.
Food interactions
[UNSAFE] Procyclidine Hydrochloride may cause excessive drowsiness with alcohol.
Use in pregnancy
[CONSULT YOUR DOCTOR] Procyclidine Hydrochloride may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Use in lactation
[CAUTION] Procyclidine Hydrochloride should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
Renal / hepatic impairment
[CAUTION] Procyclidine Hydrochloride should be used with caution in patients with kidney disease. Dose adjustment of Procyclidine Hydrochloride may be needed. Please consult your doctor. [CAUTION] Procyclidine Hydrochloride should be used with caution in patients with liver disease. Dose adjustment of Procyclidine Hydrochloride may be needed. Please consult your doctor.
Common questions
Parkinson's disease tremors ,Insomnia. Use Dhanadanayanadi kashayam 15ml twice a day with 15 ml water before food and Zandopa 10 grams twice a day witk milk after food and Tab Dhanvantari Vati 1-0-1 after food for 2 months My mother suffering from Parkinson disease from 7 year , any affective medicine ?? Both hand and leg is shaking ,hardly stand up from bed himself, using parking tablet, syndopa plus and parkitidin Dear sir Parkinson's can only be managed with Homeopathy. There are few medicines which are used to improve quality of life and decrease disease progression Parkinson's disease for 25 yrs. Taking allopathy Suggestions needed Kindly consult to any good Ayuvedic Panchkarma center. Panchkarma therapy will give you some result . Hi my mom had Parkinson's disease but didn't get any operation but using tablets syndopa last night she take another tablet of pain killer with it by the morning my mom to full shivering of hands and legs so what do u suggest to do? need to examine to opine My father suffering from Parkinson's disease Suffering from last 7year Treatment is going on of neurologist yes than what is the problem treatment for Parkinson's disease taking now syndopa cr 125, raslect n other medicine isn't this disease fully curable pls help n give u r opinion MEDICINE CONTROLS THE SYMTOMS. IF MEDICINES FAIL TO CONTROL THE DEEP BRAIN STIMULATION SURGERY IS BEING DONE. At times my fingers shiver when I hold cup, paper etc it's subconscious as in I do not notice it person Accompanying me notices I have no other health issues. Does this indicate Parkinson's disease? How is it diagnosed? not sure; show to neuro My father has parkinson's disease from last 12 year. In last 2012 he got severe pneumonia and has been admitted in AIIMS .He was treated with various antibiotics.he came out but got bed ridden after that.From last few year he just sit on his own. he is currently taking bexol 1mg three times, syndopa 125 plus 3 times, ropark XL 3 times.now from few year he got hallucination and cound not sleep in night and constantly talking in night(Some Nights not always).During his stay in AIIMS Dr. prescribed quetiapine 12.5 mg which he is not currently taking.please advice some medicien so that he atleast can sleep at night. Start Oleanz 2.5 mg at nite