৳ 4/unit
Pack: ৳ 4
৳ 4/unit
Pack: ৳ 4
At a glance
Lacidipine is a medicine used to treat high blood pressure (hypertension). It belongs to the calcium channel blocker class which helps relax blood vessels and reduce blood pressure and the workload of the heart. It helps prevent heart attacks and strokes.
Indications
- Hypertension - as monotherapy or in combination with other antihypertensive agents
Pharmacology
Lacidipine inhibits the influx of calcium into smooth muscle cells by competitive inhibition of voltage-dependent calcium 'L' channels. This action results in the inhibition of the effects triggered by calcium influx, such as activation of contractile proteins in smooth muscle.
Dosage
Oral (Adult):
- Initial dose: 2 mg once daily (preferably in the morning)
- After 3-4 weeks: May increase to 4 mg/day
- If necessary: Up to 6 mg/day
- Maximum dose: 6 mg/day
Hepatic Impairment: Reduce dose in severe liver disease.
Side effects
Common Side Effects:
- Fatigue
- Ankle swelling
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Headache
- Nausea
- Edema
- Dizziness
- Palpitations
- Abdominal pain
Rare Side Effects:
- Gastrointestinal disturbances
- Gum hyperplasia
- Aggravation of angina
- Mood disturbances
- Muscle cramps
- Skin rash
Use in pregnancy
Use in Pregnancy: Lacidipine may be unsafe during pregnancy. Animal studies have shown harmful effects on the fetus. Consult your doctor.
Precautions & warnings
- May cause dizziness or drowsiness; avoid driving or activities requiring mental focus
- Blood pressure may drop suddenly, especially when first starting; rise slowly from sitting or lying positions
- For ankle or foot swelling, elevate legs while sitting
- Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding
- Inform your doctor about any liver, kidney, or heart problems
- Discontinue if ischemic pain occurs shortly after initiating treatment
- Avoid grapefruit juice (may affect metabolism)
Overdose effects
Overdose may cause prolonged peripheral vasodilation with hypotension, tachycardia, bradycardia, or prolonged AV conduction. Symptomatic and supportive treatment is recommended.
Storage conditions
Store in a cool and dry place, protected from light and moisture; keep out of reach of children.