Larimef250mg

Mefloquine is an antiparasitic medicine, used for the treatment of malaria. It works by killing the malaria causing parasite and stops the infection from spreading. Mefloquine should be used in the dose and duration as advised by your doctor. Take it with food to decrease the risk of stomach upset. Do not skip any doses and finish the full course of treatment even if you feel better. Some people may have stomach pain, abnormal dreams, chills, depression, and diarrhea, as side effects of this medicine. Please consult your doctor if these side effects persist for a longer duration. Inform your doctor if you ever had fits (seizures) or any problems with your kidney, heart or liver. Mefloquine is an antiparasitic medication which treats malaria. It works by increasing the levels of haeme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading.

• Malaria

Mefloquine is a 4-methanolquinine antimalarial agent and a blood schizontocide which acts by interfering w/ the parasite's ability to metabolise and utilise erythrocyte Hb. It is active against most Plasmodium sp and is used for prophylaxis and treatment against malaria.

Adult Dose: Oral Acute Malaria Adult: 5 tablets (Total 1250 mg) as a single oral dose. OR 750 mg orally as initial dose, followed by 500 mg orally 6 to 12 hours after initial dose. Total dose 1,250 mg. Malaria prophylaxis 250 mg once weekly, taken 1-3 wk before exposure and continuing for 4 wk after leaving the endemic area. Dosing Considerations If a full-treatment course does not lead to improvement within 48-72 hr, mefloquine should not be used for retreatment; an alternative therapy should be used Similarly, if previous prophylaxis with mefloquine failed, mefloquine should not be used for curative treatment Child Dose: Oral Acute Malaria 6 months: 20-25 mg/kg PO as single dose. Maximum total dose: 1250 mg. OR 15 mg/kg as initial dose, followed by 10 mg/kg po given 6-12 hours after initial dose. Total dose= 25 mg/kg Malaria prophylaxis Child: 5 to 45 kg: 250 mg (1 tablet) PO qWeek Start 1-2 weeks before arrival in endemic area; continue 4 weeks after leaving endemic area

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Mefloquine is to be taken with food.

Common: • Abdominal pain • Abnormal dreams • Anxiety • Chills • Depression • Diarrhea • Dizziness • Fever • Headache • Atrial arrhythmias (altered heart rate) • Insomnia (difficulty in sleeping) • Itching • Loss of appetite • Muscle pain • Nausea • Rash • Ringing in ear • Vertigo • Visual impairment • Vomiting • Fatigue

[UNSAFE] Mefloquine may cause side effects which could affect your ability to drive. Mefloquine can cause dizziness, loss of balance and mental problems and this may affect your ability to drive. Mefloquine should be taken with food to prevent a stomach upset. Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Tips to reduce the chance of being bitten by mosquitoes: It may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you. Inform your doctor if you have kidney liver or heart disease.

Hypersensitivity to related compounds (e.g. quinine and quinidine); history of blackwater fever;, prophylactic use in patients w/ history of psychiatric (including depression) or convulsive disorders; retreatment w/ mefloquine. Severe hepatic impairment. Concomitant use w/ halofantrine.

Increased risk of ECG abnormalities w/ quinine or chloroquine, antihistamines, TCAs and phenothiazines. May increase risk of seizure w/ quinidine or quinine. Concomitant use w/ valproic acid, phenobarbital, carbamazepine and phenytoin may cause loss of seizure control and lower plasma levels of anticonvulsants. Increased risk of QT prolongation and arrhythmia w/ ketoconazole. Concomitant use w/ digoxin, Ca-channel blockers, antiarrhythmics and ?-blockers may increase the risk of cardiotoxicity. Increased risk of ventricular arrhythmias w/ amiodarone. Concomitant use w/ TCAs, SSRIs, buprion, antipsychotic, tramadol may increase the risk of convulsions. Increased plasma levels w/ metoclopromide. May compromise adequate immunisation by live typhoid vaccine. Vaccinations w/ attenuated live bacteria should be completed at least 3 days prior the 1st dose of mefloquine. Potentially Fatal: Avoid concomitant use w/ halofantrine as potentially fatal cardiac arrhythmias may occur.

[CAUTION] Caution is advised when consuming alcohol with Mefloquine. Please consult your doctor.

[CONSULT YOUR DOCTOR] Mefloquine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Mefloquine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Mefloquine in patients with kidney disease. Please consult your doctor. [CAUTION] Mefloquine should be used with caution in patients with liver disease. Dose adjustment of Mefloquine may be needed. Please consult your doctor. Use of Mefloquine is not recommended in patients with severe liver disease.

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