Laronib 100
Rx- Generic:
- Larotrectinib
- Company:
- Everest Pharmaceuticals Ltd.
- Dosage form:
- Capsule
- Pack size:
- Box (30 Capsule)
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৳ 1,166.67/unit
Pack: ৳ 35,000.10
At a glance
Larotrectinib is indicated for the treatment of patients with solid tumors that have an NTRK gene fusion, are metastatic or where surgical resection is likely to result in severe morbidity, and have no alternative treatments or have progressed following treatment.
Indications
- Solid tumors with NTRK gene fusion (metastatic or where surgical resection would cause severe morbidity, no alternative treatments or progressed following treatment)
Dosage
Adult and Pediatric (BSA ≥1 m²):
- 100 mg PO twice daily
- With or without food
- Continue until disease progression or unacceptable toxicity
Pediatric (BSA <1 m²):
- 100 mg/m² PO twice daily
Hepatic Impairment: Moderate to severe (Child-Pugh B/C): Reduce starting dose by 50%
Side effects
Common Side Effects (>10%):
- Increased AST/ALT (45%)
- Anemia (42%)
- Fatigue (37%)
- Hypoalbuminemia (35%)
- Increased alkaline phosphatase (30%)
- Nausea (29%), Dizziness (28%), Vomiting (26%)
- Cough (26%), Constipation (23%), Neutropenia (23%)
- Diarrhea (22%), Pyrexia (18%), Dyspnea (18%)
- Peripheral edema (15%), Increased weight (15%), Headache (14%)
- Arthralgia (14%), Myalgia (14%), Muscular weakness (13%)
- Decreased appetite (13%), Abdominal pain (13%), Back pain (12%)
- Pain in extremity (12%), Hypertension (11%)
Precautions & warnings
- Monitor for neurologic adverse reactions (occur in 53% of patients; most within first 3 months)
- Do not drive or operate hazardous machinery if experiencing neurologic reactions
- Monitor liver tests for hepatotoxicity (every 2 weeks during first month, then monthly)
- Can cause fetal harm in pregnant women
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.