৳ 10/unit
Pack: ৳ 100
৳ 10/unit
Pack: ৳ 100
At a glance
Dexlansoprazole is a proton pump inhibitor (PPI) used for the treatment of acid-related gastrointestinal conditions such as erosive esophagitis and non-erosive GERD.
Indications
- Healing of erosive esophagitis (up to 8 weeks)
- Maintenance of healed erosive esophagitis (up to 6 months)
- Treatment of heartburn associated with symptomatic non-erosive GERD (4 weeks)
Pharmacology
Dexlansoprazole delayed-release capsule is a PPI which suppresses gastric acid secretion by specific inhibition of the (H+/K+)-ATPase in the gastric parietal cell. It is the R-enantiomer of lansoprazole and is supplied as a Dual Delayed Release (DDR) formulation.
Dosage
Healing of erosive esophagitis: 60 mg once daily (up to 8 weeks).
Maintenance of healed erosive esophagitis: 30 mg once daily (up to 6 months).
Non-erosive GERD: 30 mg once daily (4 weeks).
Moderate hepatic impairment (Child-Pugh B): Not to exceed 30 mg/day.
Children (12-17 years): Maintenance 30 mg once daily (16 weeks).
Side effects
Common: Diarrhea, abdominal pain, nausea, vomiting, flatulence.
Other: Headache, constipation, dry mouth.
Use in pregnancy
Pregnancy Category B. Dexlansoprazole is generally considered safe during pregnancy. Animal studies have shown low or no adverse effects; however, there are limited human studies.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
Gastric malignancy, Clostridium difficile-associated diarrhea, bone fracture (with long-term use), hypomagnesemia, and concomitant use with methotrexate. Inform doctor if no improvement within 14 days. With long-term use, take calcium and vitamin D supplements.
Overdose effects
There have been no reports of a significant overdose. Multiple doses of 120 mg and a single dose of 300 mg did not result in death or other severe adverse events.
Storage conditions
Store below 30°C temperature & in a dry place, protected from light. Keep out of reach of children.