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At a glance

Cyclobenzaprine Hydrochloride is a muscle relaxant used to relieve muscle spasm associated with acute, painful musculoskeletal conditions.

Indications
  • Muscle spasm associated with acute, painful musculoskeletal conditions
  • Muscle relaxation
Pharmacology

Cyclobenzaprine, a centrally-acting skeletal muscle relaxant, is structurally related to tricyclic antidepressants, thus they share similar properties. It acts on the brain stem, decreasing tonic-somatic motor activities influencing both the α and δ motor systems. It is used as an adjunct in the symptomatic treatment of painful muscle spasms associated with musculoskeletal conditions.

Dosage

Adult Dose: 5 mg three times daily, may increase to 10 mg three times daily if needed. Maximum daily dose: 60 mg. Treatment should not last more than 2-3 weeks.

Elderly: Initiate with 5 mg dose and titrate slowly upward.

Child (15 years & above): 5 mg every 8 hours, may increase to 10 mg every 8 hours PRN.

Side effects

Common Side Effects:

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Tiredness
  • Headache
Use in pregnancy

Pregnancy Category B. Animal studies have shown low or no adverse effects, but human studies are limited. Should be used during pregnancy only if clearly needed.

Pregnancy Category: B — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • This medicine may affect your ability to drive.
  • Due to its atropine-like action, use with caution in patients with urinary retention, angle-closure glaucoma, or taking anticholinergic medication.
  • Use with caution in patients with liver disease. Not recommended in moderate to severe liver disease.
Overdose effects

Deaths may occur from overdosage. Signs and symptoms of toxicity may develop rapidly, so hospital monitoring is required as soon as possible.

Storage conditions

Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.

Cyclobenzaprine Hydrochloride — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.