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At a glance
Letrozole is used for the treatment of breast cancer in postmenopausal women and infertility due to anovulation. It is an aromatase inhibitor that decreases the amount of estrogen in the body.
Indications
- Hormone receptor-positive early breast cancer - adjuvant therapy (postmenopausal)
- Early breast cancer - extended adjuvant therapy (after 5 years of tamoxifen)
- Hormone-dependent advanced breast cancer - first-line therapy (postmenopausal)
- Advanced breast cancer - post-antioestrogen therapy (postmenopausal)
- Localized hormone receptor-positive breast cancer - preoperative therapy
- Infertility due to anovulation
Dosage
Adult Dose (Oral):
- 2.5 mg once daily
- Adjuvant and extended adjuvant: 5 years or until tumor relapse
- Metastatic disease: until tumor progression
- Severe hepatic impairment (cirrhosis, Child-Pugh C): Reduce dose by 50% (2.5 mg every other day)
Side effects
Common Side Effects:
- Hot flashes
- Hypercholesterolemia (high cholesterol)
- Fatigue
- Increased sweating
- Bone and joint pain (arthralgia)
- Skin rash
- Headache, dizziness
- Nausea, vomiting, dyspepsia, constipation, diarrhea
- Osteoporosis
- Edema
- Weight gain
Precautions & warnings
- Monitor liver function; dose reduction needed in severe hepatic impairment
- Monitor cholesterol and bone mineral density regularly
- Caution when driving or activities requiring concentration (may cause fatigue and dizziness)
- Contraindicated during pregnancy and lactation
- Do not use in premenopausal women
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.