osudhkosh
New
Company•Incepta Pharmaceuticals Ltd.

Lenvacent 10

Rx
Generic: Lenvatinib Mesylate

৳ 1,750/unit

Pack: ৳ 1,750

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At a glance

Lenvatinib Mesylate is an oral receptor tyrosine kinase inhibitor used in the treatment of thyroid cancer, renal cell carcinoma (RCC), hepatocellular carcinoma (HCC), and endometrial carcinoma.

Indications
  • Differentiated thyroid cancer (DTC) - locally recurrent or metastatic, radioactive iodine-refractory
  • Renal cell carcinoma (RCC) - in combination with Everolimus, following prior anti-angiogenic therapy
  • Hepatocellular carcinoma (HCC) - first-line treatment for unresectable HCC
  • Endometrial carcinoma - in combination with Pembrolizumab (non-MSI-H or dMMR)
Pharmacology

Lenvatinib inhibits the kinase activities of VEGFR1-3, FGFR1-4, PDGFR-α, KIT, and RET, blocking angiogenesis, tumor growth, and cancer progression.

Dosage

Differentiated Thyroid Cancer (DTC): 24 mg PO once daily

Renal Cell Carcinoma (RCC): 18 mg PO once daily + Everolimus 5 mg

Hepatocellular Carcinoma (HCC): ≥60 kg: 12 mg; <60 kg: 8 mg PO once daily

Endometrial Carcinoma: 20 mg PO once daily + Pembrolizumab 200 mg IV every 3 weeks

Severe Renal/Hepatic Impairment: DTC: 14 mg; RCC/Endometrial: 10 mg once daily

Side effects

Common Side Effects:

  • Hypertension
  • Diarrhea
  • Fatigue
  • Joint and muscle pain
  • Nausea and vomiting
  • Decreased appetite
  • Weight loss
  • Skin rash and peeling
  • Mouth sores
  • Cough, hoarseness
  • Proteinuria
  • Hypocalcemia
  • QT interval prolongation
Use in pregnancy

Use in Pregnancy: Lenvatinib may be unsafe during pregnancy; animal studies have shown harmful effects on the fetus. Use effective contraception for at least 30 days after the last dose.

Precautions & warnings
  • Control blood pressure; monitor after 1 week, then every 2 weeks for first 2 months, then monthly
  • Monitor liver function every 2 weeks for first 2 months, then monthly
  • Monitor for proteinuria
  • Manage diarrhea with fluids; inform your doctor
  • Risk of severe hemorrhage (tumor invasion/infiltration)
  • Withhold for at least 6 days prior to surgery
  • Can cause fetal harm during pregnancy
Overdose effects

Overdose treatment: observation and supportive measures; death due to multiorgan dysfunction occurred with 120 mg single dose. Dialysis is not expected to be effective.

Storage conditions

Store below 30°C in a dry place, protected from light; keep out of reach of children.

Lenvatinib Mesylate — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.