osudhkosh
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Company•Square Pharmaceuticals PLC.

Liglimet 500

2.5mg+500mgRx
Generic: Linagliptin + Metformin Hydrochloride

৳ 13/unit

Pack: ৳ 78

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At a glance

Linagliptin + Metformin Hydrochloride is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. It reduces glucose production, increases insulin sensitivity, and enhances incretin hormone activity.

Indications
  • Type 2 diabetes mellitus - as an adjunct to diet and exercise to improve glycemic control
Pharmacology

Linagliptin inhibits the DPP-4 enzyme, increasing incretin hormone (GLP-1 and GIP) levels, which stimulates glucose-dependent insulin release and reduces glucagon secretion. Metformin decreases hepatic glucose production, reduces intestinal glucose absorption, and increases insulin sensitivity.

Dosage

Immediate Release Tablets:

  • Not currently taking metformin: 2.5 mg/500 mg twice daily
  • Already taking metformin: 2.5 mg linagliptin with current metformin dose twice daily
  • Maximum dose: 2.5 mg/1,000 mg twice daily

Extended Release Tablets:

  • Not currently taking metformin: 5 mg/1,000 mg once daily
  • Already taking metformin: 5 mg linagliptin + equivalent metformin dose once daily
  • Maximum daily dose: Linagliptin 5 mg + Metformin 2,000 mg
Side effects

Common Side Effects:

  • Diarrhea
  • Nausea
  • Vomiting
  • Upset stomach
  • Headache
  • Nasal congestion
  • Sore throat
  • Respiratory tract infection
  • Hypoglycemia (with insulin or sulfonylurea)
Use in pregnancy

Use in Pregnancy: Linagliptin + Metformin is generally considered safe during pregnancy (Category B). Animal studies have shown low or no adverse effects to the developing baby.

Pregnancy Category: B — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Inform doctor immediately if symptoms of lactic acidosis occur (deep/rapid breathing, persistent nausea, vomiting, stomach pain)
  • Monitor blood sugar regularly to avoid hypoglycemia
  • Avoid alcohol (risk of hypoglycemia and lactic acidosis)
  • Temporarily stop before major surgery or contrast dye procedures
  • Monitor liver and kidney function regularly
Overdose effects

Overdose: supportive measures; Metformin is dialyzable, Linagliptin is not. Lactic acidosis has been reported in metformin overdose.

Storage conditions

Store below 30°C in a cool and dry place, protected from light and moisture; keep out of reach of children.

Linagliptin + Metformin Hydrochloride — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.