Lindamax Plus

• Acne vulgaris

Clindamycin: Antibacterial agent that binds to the 50S ribosomal subunits of susceptible bacteria and prevents elongation of peptide chains by interfering with peptidyl transfer, thereby suppressing protein synthesis; reduces surface fatty acids on skin; exact mechanism of action in treating acne unknown. Tretinoin: Exact mechanism unknown; appears to increase cohesiveness of follicular epithelial cells with decrease microcomedo formation; also increases turnover of follicular cells to cause extrusion of comedones.

Adult Dose (Acne Vulgaris): Apply a pea-size amount of gel once daily preferably at bedtime. Treatment should be continued for 12 weeks.

Pediatric Dose (12 years): Apply a pea-size amount of gel once daily preferably at bedtime.

Common Side Effects:

• Application site reactions (burning, stinging, itching and redness)
• Dryness
• Skin peeling
• Dermatitis

[CONSULT YOUR DOCTOR] Clindamycin Phosphate 1.2% + Tretinoin 0.025% Topical may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Pregnancy Category C.

• Apply as a thin layer onto clean, dry, unbroken skin affected by acne.
• Allow skin to dry for 20-30 minutes before application.
• Avoid contact with your eyes, nose or mouth. Rinse with water if accidental contact occurs.
• Avoid exposure to sunlight as it increases skin sensitivity; use sunscreen or protective clothing.
• Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
• Use with caution in individuals with a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis.

Excessive application may result in severe irritation. Discontinue use and wait until the skin has recovered. In the event of accidental ingestion, gastrointestinal adverse reactions similar to those seen with systemically administered clindamycin may be seen.

Store in a cool and dry place, away from light and out of reach of children.