Liorel 5

• Spasticity resulting from multiple sclerosis
• Flexor spasms and concomitant pain, clonus and muscular rigidity
• Skeletal muscle spasm resulting from rheumatic disorders
• Spinal cord injuries and other spinal cord diseases
• Cerebrovascular accidents or neoplastic or degenerative brain disease

Baclofen stimulates GABA-B receptors at the spinal level, inhibiting both monosynaptic and polysynaptic reflexes, which reduces the release of glutamate and aspartate and decreases excessive muscle contraction. It also acts at intraspinal sites producing CNS depression and exerts an antinociceptive effect.

Adults and children over 10 years:

• Initial dose: 5 mg 3 times daily (with or after food), gradually increased
• Dose titration: 5 mg tid for 3 days → 10 mg tid for 3 days → 20 mg tid or until desired effect
• Maximum dose: 100 mg daily

Children under 10 years:

• Initial dose: 2.5 mg (2.5 ml) 4 times daily, gradually increased
• Maintenance dose:
  • 12 months-2 years: 10-20 mg/day
  • 2-6 years: 20-30 mg/day
  • 6-10 years: 30-60 mg/day
• Maximum: >10 years: 2.5 mg/kg/day

Elderly: Initiate with lower doses.

Renal impairment: Dose reduction may be required (approximately 5 mg/day).

• Transient drowsiness
• Daytime sedation
• Dizziness
• Weakness and fatigue
• Headache (<10%)
• Insomnia (<10%)
• Nausea (~10%)
• Constipation (<10%)
• Hypotension (<10%)
• Urinary frequency (<10%)

Rare: Euphoria, excitement, depression, confusion, hallucinations, paraesthesia, nightmares, muscle pain, tinnitus, blurred vision, epileptic seizures, respiratory depression, erectile dysfunction, rash, pruritus, weight gain, etc.

[CONSULT YOUR DOCTOR] Safety during pregnancy has not been established (Category B3). Baclofen crosses the placental barrier. Use only if clearly needed and under medical supervision.

• Caution when driving or operating machinery (may cause drowsiness and dizziness)
• Avoid alcohol consumption
• Do not stop suddenly after long-term use
• Use lower doses in renal impairment (approximately 5 mg/day)
• Caution and close monitoring in patients with psychotic disorders, schizophrenia, depression, or manic disorders
• May lower seizure threshold in epilepsy patients
• Caution in patients with peptic ulcer, cerebrovascular disease, hepatic, renal, or respiratory failure
• Caution during pregnancy and lactation

Symptoms: Severe overdose requires gastric lavage. Respiratory depression, seizures, coma may occur.

Management: Gastric lavage, symptomatic and supportive treatment.

Store below 30°C, away from light and moisture. Keep out of reach of children.