Lotepro G
0.5%+0.3%Rx৳ 250/unit
Pack: ৳ 250
৳ 250/unit
Pack: ৳ 250
At a glance
Loteprednol + Gatifloxacin eye prep is used for bacterial eye infections. Gatifloxacin kills bacteria and Loteprednol reduces inflammation, redness, and itching in the eye.
Indications
- Steroid-responsive inflammatory ocular conditions (allergic conjunctivitis, keratitis, iritis, cyclitis)
- Post-operative inflammation
- Conditions with superficial bacterial ocular infection or risk
Pharmacology
Loteprednol induces lipocortins to inhibit arachidonic acid release, controlling inflammatory mediator biosynthesis. Gatifloxacin inhibits DNA gyrase and topoisomerase IV to prevent bacterial DNA replication.
Dosage
Adult Dose (Eye Drop):
- Instill 1-2 drops into conjunctival sac of affected eye(s) every 4-6 hours
- May increase to every 1-2 hours during first 24-48 hours
- Decrease frequency gradually as clinical signs improve
Side effects
Common Side Effects (5-10%):
- Conjunctival irritation
- Increased lacrimation
- Keratitis
- Papillary conjunctivitis
Other (1-4%):
- Chemosis, conjunctival hemorrhage, dry eye, eye discharge
- Eye irritation, pain, eyelid edema
- Headache, red eye, reduced visual acuity, taste disturbance
Use in pregnancy
Use in Pregnancy: Loteprednol + Gatifloxacin eye prep may be unsafe during pregnancy (Category C); animal studies have shown harmful effects on the fetus. Use only if benefits outweigh risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Monitor intraocular pressure if used for 10 days or longer
- Consider fungal invasion in any persistent corneal ulceration
- If using soft contact lenses, wait at least 10 minutes before inserting after drops
- Do not inject subconjunctivally or into the anterior chamber
Overdose effects
No specific overdose information available; symptomatic and supportive measures should be employed.
Storage conditions
Store at room temperature, protected from light; protect from freezing; use within 1 month of opening; keep out of reach of children.