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Lorazepam is a prescription medicine used to treat anxiety disorders such as generalized anxiety disorder (excessive worry or restlessness), obsessive compulsive disorder (OCD), panic attacks and social phobias. It is also used for the short-term relief of the symptoms of anxiety. Lorazepam relieves symptoms of anxiety such as nervousness, rapid breathing, increased heart rate, excessive sweating, trembling, weakness or lack of concentration. It may be taken with or without food. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it has a high potential of habit-forming. If you have missed any doses, take it as soon as you remember it and finish the full course of treatment even if you feel better. You should not stop this medication without talking to your doctor as it may cause nausea and anxiety. Some common side effects of this medicine include weakness, sedation and balance disorder (loss of balance). It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Talk to your doctor about potential side effects and ways you might prevent or cope with them. You may also get side effects after stopping the treatment. Before taking the medicine you should tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Taking it along with alcohol affects the way it works and can increase the chance of side effects. If you have been taking this medicine for a long time then regular monitoring of blood and liver functions may be required. Lorazepam is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.

• Short term anxiety • Anxiety disorder

Lorazepam is a short acting benzodiazepine. It increases neuronal membrane permeability to Cl ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS (including the limbic system, reticular formation) and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.

Adult Dose: Oral Anxiety Disorders Adult: 1-6 mg/day in 2 or 3 divided doses, up to 10 mg/day. Insomnia associated w/ anxiety 1-4 mg/day at bedtime. Premed in surgery 2-3 mg the night before operation, then a smaller dose in the morning if needed. Parenteral Preoperative Sedation, Anxiety Relief, & Anterograde Amnesia 0.05 mg/kg IM for 1 dose; 2 hours before surgery; not to exceed 4 mg (2 mg/dose in elderly), OR 0.044 mg/kg IV for 1 dose; 15-20 minutes before surgery; not to exceed 4 mg (2 mg/dose in elderly) Status Epilepticus Usual 4 mg/dose slow IV at 2 mg/min If seizure persists after 5-10 min, administer 4 mg IV again Anxiolytic/Sedation in ICU Intubated and mechanically ventilated patients 0.02-0.04 mg/kg loading dose IV 0.02-0.06 mg/kg intermittent IV q2-6hr PRN, OR 0.01-0.1 mg/kg/hr continuous IV; not to exceed 10 mg/hr Elderly: Half the usual adult dose or less. Hepatic impairment: Mild to moderate: May require reduced doses. Severe: Contraindicated. Child Dose: Status Epilepticus Infants and children: 0.05-0.1 mg/kg IV over 2-5 minutes; not to exceed 4 mg/dose; may repeat q10-15min PRN Alternatively, 0.1 mg/kg at slow IV rate not to exceed rate of 2 mg/min; not to exceed dose of 4 mg Adolescents: 4 mg slow IV; if seizure persists after 10-15 minutes, administer 4 mg IV again Renal Dose: Renal impairment PO: Dose adjustment not necessary IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment or renal failure

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lorazepam may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Lorazepam, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Dizziness • Weakness • Sedation • Balance disorder (loss of balance)

[UNSAFE] Lorazepam may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. The addiction / habit-forming potential of this medicine is very high. Take it only as per the dose and duration advised by your doctor It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid consuming alcohol as it may increase dizziness and drowsiness. Inform your doctor if you are pregnant, planning to conceive or breastfeeding. Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.

Severe hepatic impairment; respiratory depression; acute narrow-angle glaucoma; pregnancy and lactation.

Drugs that affect the CNS (e.g. barbiturates, phenothiazines, antidepressants, MAOIs) may have additive CNS effects. Scopolamine may increase sedation, hallucinations and irrational behaviour. May reduce sedative and anxiolytic effect w/ caffeine, theophylline or aminophylline. May increase plasma level w/ Na valproate or probenecid.

[UNSAFE] It is unsafe to consume alcohol with Lorazepam.

[CONSULT YOUR DOCTOR] Lorazepam is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[CONSULT YOUR DOCTOR] Lorazepam is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. Lorazepam should be used for short periods and sleepiness of the baby should be watched. The withdrawal of Lorazepam should be gradual.

[CAUTION] Lorazepam should be used with caution in patients with severe kidney disease. Dose adjustment of Lorazepam may be needed. Please consult your doctor. However, inform your doctor if you have any underlying kidney disease. [CAUTION] Lorazepam should be used with caution in patients with severe liver disease. Dose adjustment of Lorazepam may be needed. Please consult your doctor. Use of Lorazepam is not recommended in patients with severe liver disease.

I feel short term memory loss , anxiety and mood disorder Do Mri brain and thyroid testing Taking Trapex for 2yrs. due to insomnia and anxiety. But Trapex is not available in Kolkata right now. So which medicines can I take as substitute. (P.S.: Can I take ATIVAN 2mg as substitute) Ativan is lorazepam and can be used as a substitute brand. Regular use of lorazepam isn't recommended. Which medicine long-term use are harmful?? Ativan Amixide h. Nexito plus Alprazolam CONSULT psychiatrist for this Sir I am suffering with social anxiety. I have no courage to face and speak with people.sir now I take the medicine sulpitac 100mg,oxetol 600mg and ativan 2mg. Based on your clinical history, your doctor plans the type of medicine and it's dose and duration. For first episode of anxiety/ depression/ panic, the usual maintenance phase is 6 months of asymptomatic period, after which medicines can be gradually tapered. But treatment may need to continue longer depending on severity and frequency of episodes. To take any decision to change medication or stop them, several factors have to be taken in account for which regular follow up with your psychiatrist is important. For second opinion, seek a proper consultation with another psychiatrist and take along your previous prescriptions. i am suffering from anxiety disorder and i am on anxiety medications does ayurveda has any treatment for anxiety disorder Yes, Panchkarma is the best you should take sitting of sirodhara Mixed anxiety depressive disorder Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended. Generalized anxiety disorder problem Anxiety is the result of a hyperarousal state of nervous system due to a low threshold for threat perception. In simpler words, it's an ongoing flight or fight response. It can elicit a neuro-hormonal response understood as Flight or Fright reaction kicking in physiological cascade of symptoms ranging from palpitations, tachycardia, breathlessness, increased bowel movement, increase frequency of urination, dizziness, muscle tension or pain, trembling, dizziness, blurring of vision to restlessness, confusion and fainting spells. Chronic stress causes prolonged anxiety response with the consequences of slowed me ration, lack of concentration, headaches, fluctuations in blood pressure and increased wear and tear of body tissues. Identifying your stressors, learning to deal with them, de stressing regularly by doing something that makes one feel good, yoga and meditation are some non pharmacological strategies to deal with it. If the condition is persisting for a long time, it's better to see a psychiatrist. Mental Depression , Anxiety disorder Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.