৳ 15.05/unit
Pack: ৳ 150.50
৳ 15.05/unit
Pack: ৳ 150.50
At a glance
Lubiprostone is a prescription medicine used for the treatment of constipation and irritable bowel syndrome. It works by increasing fluid secretion in the intestine, making stool soft and easier to pass.
Indications
- Chronic idiopathic constipation in adults
- Opioid-induced constipation in adults
- Irritable bowel syndrome with constipation (IBS-C) in women >18 years
Pharmacology
Lubiprostone specifically activates ClC-2 chloride channels to increase chloride-rich intestinal fluid secretion, enhancing intestinal motility and relieving constipation.
Dosage
Chronic Idiopathic Constipation: 24 mcg twice daily with food
Opioid-Induced Constipation: 24 mcg twice daily with food
IBS-C: 8 mcg twice daily with food
Hepatic Impairment: Moderate (Child-Pugh B): Constipation 16 mcg twice daily; IBS-C: no dose adjustment; Severe (Child-Pugh C): Constipation 8 mcg twice daily; IBS-C: 8 mcg once daily
Side effects
Common Side Effects:
- Nausea
- Headache
- Abdominal pain
- Abdominal distension
- Diarrhea
- Flatulence
- Vomiting
- Dry mouth
- Dizziness
Use in pregnancy
Use in Pregnancy: Lubiprostone may be unsafe during pregnancy (Category C); animal studies have shown harmful effects on the fetus. Use only if benefits outweigh risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Taking with food may reduce nausea
- Seek medical attention if severe diarrhea, breathlessness, chest pain, or chest tightness occurs
- Confirm absence of mechanical GI obstruction before starting treatment
- Not recommended in children under 18 years
- Consult doctor during pregnancy and lactation
Overdose effects
Overdose adverse reactions: nausea, diarrhea, vomiting, dizziness, headache, and abdominal pain.
Storage conditions
Keep out of reach of children; store below 25°C in a cool and dry place, protected from light.