৳ 6.50/unit
Pack: ৳ 65
৳ 6.50/unit
Pack: ৳ 65
At a glance
Maprotiline Hydrochloride is a tetracyclic antidepressant used for the treatment of depressive illness and anxiety associated with depression. It works by inhibiting the re-uptake of noradrenaline at nerve endings.
Indications
- Depressive illness (depressive neurosis/dysthymic disorder)
- Manic depressive illness (major depressive disorder)
- Relief of anxiety associated with depression
Pharmacology
Maprotiline potentiates central adrenergic synapses by blocking reuptake of norepinephrine at nerve endings, which is responsible for its antidepressant and anxiolytic effects.
Dosage
Adult Dose (Oral):
- Mild-moderate depression (outpatients): Initial 75 mg daily; may increase in 25 mg increments up to 150 mg daily
- Severe depression (hospitalized): 100-150 mg daily; max 225 mg daily
- Maintain initial dose for 2 weeks
Elderly (>60 years): Initial 25 mg daily; maintenance 50-75 mg daily
Side effects
Common Side Effects:
- Fatigue, sedation, lethargy, weakness
- Constipation, dry mouth, blurred vision
- Dizziness, tremor
- Nausea, vomiting
Less Common:
- Anxiety, agitation, insomnia
- Orthostatic hypotension, ECG changes
- Rash, elevated liver enzymes
Use in pregnancy
Use in Pregnancy: Maprotiline is considered safe during pregnancy (Category B); animal studies have shown no fetal harm. Use only if clearly needed.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in urinary retention, prostatic hyperplasia, chronic constipation, untreated angle-closure glaucoma
- Caution in hyperthyroidism
- Risk of suicide (especially early in treatment)
- May precipitate mania or psychotic symptoms
- Withdraw gradually
- May impair ability to operate machinery
Overdose effects
Overdose may cause seizures, cardiovascular toxicity, CNS depression; symptomatic treatment.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.