Marvelous Plus-FE

• Contraception
• Treatment of irregular periods

Desogestrel is a progestogen that is structurally related to levonorgestrel while ethinylestradiol is a synthetic oestrogen. Used together, they inhibit ovulation by a negative feedback mechanism on the hypothalamus, which alters the normal FSH and LH secretion pattern by the anterior pituitary. It also causes changes in the cervical mucus, making it unsuitable for sperm penetration and may alter tubal transport of the ova.

Adult (21-day pack): Start on Day 1 of menstrual cycle. Take 1 tablet daily for 21 days, followed by 7 pill-free days. Start new pack on Day 8.
Adult (28-day pack): Start on Day 1, take 1 tablet daily without interruption.

Common: Nausea, stomach pain, headache, irregular uterine bleeding, weight gain, breast pain.
Other: Diarrhea, fluid retention, migraine, depressed mood, decreased libido, rash.

Pregnancy Category X. Desogestrel + Ethinylestradiol is highly unsafe during pregnancy. Studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Risk of thromboembolism; caution in smoking, obesity, age >35; discontinue if signs of blood clot; caution in diabetes, hypertension, liver disease; monitor blood pressure, cholesterol, and blood sugar.

Overdose may cause nausea, vomiting, and vaginal bleeding. No serious harmful effects have been reported.

Store below 30°C.